INT21248

Context Info Confidence 0.59 First Reported 1983 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 5.16 Pain Relevance 2.50

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)

Anatomy Link Frequency canal 1 nerve 1 pores 1 brain 1 Lamina 1 Lta (Mus musculus)

Pain Link Frequency Relevance Heat Neurotransmitter 26 100.00 excitatory amino acid 1 100.00 bradykinin 4 99.52 Glutamate 2 99.44 Bile 43 99.36 Inflammation 76 97.12 COX2 3 95.36 interstitial cystitis 2 95.08 long-term potentiation 10 93.24 antagonist 17 91.24

Disease Link Frequency Relevance Heat Cancer 32 99.98 Urticaria 61 99.62 Overactive Bladder 24 98.48 Hepatocellular Cancer 89 98.38 Pressure And Volume Under Development 19 98.20 Cholangitis 2 98.20 INFLAMMATION 87 97.12 Biliary Liver Cirrhosis 22 96.08 Interstitial Cystitis 2 95.08 Acid Reflux 2 92.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One speculation is that from the hepatocytes, via bile canaliculi to Herring's canal, LTA was secreted and finally reached the interlobular bile ducts.

Localization (secreted) of LTA in canal associated with bile

1) Confidence 0.59 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.21 Pain Relevance 0.36

In our observation, the pattern of LTA localization depends on the pathological stage, with marked differences between stages [11].

Localization (localization) of LTA

2) Confidence 0.59 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.70 Pain Relevance 0.11

-latrotoxin (LTX), which increases the rate of spontaneous neurotransmitter release from nerve terminals.

Localization (release) of LTX in nerve associated with neurotransmitter

3) Confidence 0.36 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.13

The cytoprotective effect of PGE2 is likely to be lost when the mucosa is damaged, and LT release from deeper layers may contribute significantly to symptoms of bladder inflammation.

Localization (release) of LT in bladder associated with inflammation

4) Confidence 0.23 Published 1994 Journal J. Urol. Section Abstract Doc Link 8015109 Disease Relevance 0.66 Pain Relevance 0.22

Finally, in whole cell voltage-clamp studies of Lamina I neurons, DAMGO inhibited excitatory postsynaptic current (EPSC) response amplitudes from LT stimulation-evoked excitatory amino acid release but not from glutamate puffed onto the cell and increased paired-pulse facilitation of EPSCs evoked by LT stimulation.

Localization (release) of LT in Lamina associated with glutamate and excitatory amino acid

5) Confidence 0.22 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11160487 Disease Relevance 0.06 Pain Relevance 0.97

Under the same conditions, net release of leukotriene (LT) was observed predominantly from the detrusor.

Localization (release) of LT associated with overactive bladder

6) Confidence 0.17 Published 1994 Journal J. Urol. Section Abstract Doc Link 8015109 Disease Relevance 0.60 Pain Relevance 0.18

Mediator compounds such as bradykinin, arachidonic acid, and LT are released in the brain in conditions causing cerebral swelling.

Localization (released) of LT in brain associated with pressure and volume under development and bradykinin

7) Confidence 0.17 Published 1990 Journal Adv Neurol Section Abstract Doc Link 2168664 Disease Relevance 0.26 Pain Relevance 0.17

Current therapeutic strategies for HCC can be devided into established therapies such as surgical interventions (tumor resection and LTx), percutaneous interventions (ethanol injection, radiofrequency thermal ablation), transarterial interventions (embolization, chemoperfusion, or chemoembolization), and experimental strategies such as radiation therapy and drugs, including gene and immune therapy.

Localization (resection) of LTx associated with cancer and hepatocellular cancer

8) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 1.01 Pain Relevance 0

LT and TXB2 release was reduced by tepoxalin in both doses used.

Localization (release) of LT

9) Confidence 0.11 Published 1998 Journal Acta Orthop Scand Section Abstract Doc Link 9703407 Disease Relevance 0.30 Pain Relevance 0.07

A23187 induced a bell-shaped concentration-dependent release of [3H]-LT which peaked at 1 X 10(-6)M ionophore.

Localization (release) of LT

10) Confidence 0.10 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6316436 Disease Relevance 0.07 Pain Relevance 0.07

In patients with chronic urticaria, baseline urinary LT E4 excretion is higher in patients sensitive to ASA than in patients insensitive to ASA (1).

Localization (excretion) of LT E4 associated with urticaria

11) Confidence 0.09 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779320 Disease Relevance 1.30 Pain Relevance 0.18

-LTX that translocate into the cytosol.

Localization (translocate) of LTX

12) Confidence 0.05 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0.04

-LTX, formation of ?

Localization (formation) of LTX

13) Confidence 0.05 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0

-LTX seems to form pores and can conceivably lead to uncontrolled release from target cells.

Localization (release) of LTX in pores

14) Confidence 0.04 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0

NG-monomethyl-L-arginine caused a 50%-60% reduction of LT-induced pepsinogen release.

Localization (release) of LT-induced

15) Confidence 0.00 Published 1995 Journal Gastroenterology Section Body Doc Link 7768375 Disease Relevance 0 Pain Relevance 0

General Comments

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