INT212510

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 26
Total Number 31
Disease Relevance 15.20
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
immune system 2
Peyer's patch 1
apoptotic cells 1
MR1 1
T-cells 1
Apcs (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 188 99.44 Very High Very High Very High
Potency 8 97.72 Very High Very High Very High
Bioavailability 8 93.92 High High
Inflammatory response 162 90.88 High High
Inflammation 422 76.40 Quite High
cva 20 75.12 Quite High
tolerance 18 50.00 Quite Low
chemokine 23 30.20 Quite Low
anesthesia 30 5.00 Very Low Very Low Very Low
halothane 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 152 100.00 Very High Very High Very High
Amyloid Plaque 12 99.84 Very High Very High Very High
Infection 819 99.80 Very High Very High Very High
Amyloidosis 21 99.68 Very High Very High Very High
Pneumonia 320 99.56 Very High Very High Very High
Sprains And Strains 882 99.44 Very High Very High Very High
Bacterial Meningitis 80 99.40 Very High Very High Very High
Disease 101 99.20 Very High Very High Very High
Cellulitis 20 99.08 Very High Very High Very High
Apoptosis 44 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SAP binding to S. pneumoniae was analysed by whole-cell ELISA as previously described [54].
SAP Spec (analysed) Binding (binding) of
1) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.47 Pain Relevance 0
In contrast, SAP does not bind to or affect phagocytosis of a smooth strain of E. coli, and SAP-deficient mice had increased susceptibility to this E. coli strain by unknown mechanisms [29,30].
SAP Neg (not) Binding (bind) of associated with sprains and strains
2) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 1.65 Pain Relevance 0
SAP binds to DNA, chromatin, and apoptotic cells, and is thought to aid their clearance [3,4].
SAP Binding (binds) of in apoptotic cells associated with apoptosis
3) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.77 Pain Relevance 0
However, by binding to amyloid fibrils and stabilising their structure, SAP also promotes amyloid persistence and is therefore an important component of the disease amyloidosis [5–7].
SAP Binding (binding) of associated with amyloidosis, alzheimer's dementia and disease
4) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.86 Pain Relevance 0
As a consequence, SAP can bind to a range of microbes, including Gram-positive and Gram-negative bacterial pathogens and human influenza A virus [21,22].
SAP Binding (bind) of associated with influenza virus infection
5) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.70 Pain Relevance 0
Interactions of SAP with the immune system have also been described, the physiological relevance of which is not clear.
SAP Spec (clear) Binding (Interactions) of in immune system
6) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.84 Pain Relevance 0
Using flow cytometry assays, we show that SAP binds to S. pneumoniae, increases classical pathway–dependent deposition of complement on the bacteria, and improves the efficiency of phagocytosis.
SAP Binding (binds) of
7) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1971117 Disease Relevance 0.79 Pain Relevance 0.04
In addition, SAP can bind to structures found on microbial surfaces, including lipopolysaccharide (LPS), phosphorylcholine (PC), and terminal mannose or galactose glycan residues [16–20].
SAP Binding (bind) of
8) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.69 Pain Relevance 0
SAP can bind to molecular patterns found on the surface of bacteria, and it has been proposed that this may mark bacteria for attack by the immune system.
SAP Binding (bind) of in immune system
9) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1971117 Disease Relevance 0.92 Pain Relevance 0.03
ELISA for SAP binding to S. pneumoniae.
SAP Binding (binding) of
10) Confidence 0.37 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.48 Pain Relevance 0
Significant levels of SAP binding still occurred in the presence of PC or high concentrations of EDTA, and this might reflect some non-specific binding of SAP to S. pneumoniae.
SAP Binding (binding) of
11) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.50 Pain Relevance 0
As SAP from different mammalian species can bind both to PC and C1q [9,10,16,17], we hypothesised that SAP could also contribute to the activation of the classical pathway by S. pneumoniae, and therefore aid both innate and acquired immunity to this important pathogen.
SAP Binding (bind) of
12) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.38 Pain Relevance 0
These data show that SAP can bind to a range of S. pneumoniae strains, and therefore could potentially act as a pathogen recognition receptor and mediate innate immune responses to this pathogen.


SAP Binding (bind) of associated with sprains and strains
13) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.48 Pain Relevance 0
Significant levels of SAP binding still occurred in the presence of PC or high concentrations of EDTA, and this might reflect some non-specific binding of SAP to S. pneumoniae.
SAP Spec (might) Binding (binding) of
14) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.48 Pain Relevance 0
For example, de Haas et al. have reported that in direct contrast to the results presented in this manuscript, binding of SAP to the LPS expressed by some E. coli strains inhibits classical pathway–mediated complement activity, perhaps by preventing direct binding of C1q to LPS [29].
SAP Binding (binding) of associated with sprains and strains
15) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.42 Pain Relevance 0
In addition, S. pyogenes does not express PC on its surface, and to which bacterial surface structure SAP binds may influence its functional role and interactions with complement factors.
SAP Binding (binds) of in surface structure
16) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.37 Pain Relevance 0
Furthermore, the presence of PC inhibited binding of both SAP and CRP (used as a positive control, as CRP is known to bind to S. pneumoniae cell wall PC) to a similar degree, suggesting that PC is a major ligand for SAP binding to S. pneumoniae (Figure 1D and 1E).
SAP Binding (binding) of
17) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.56 Pain Relevance 0
The results of C3b deposition, C1q, CRP and SAP binding experiments, cytokine levels, and phagocytosis assays were analysed using 2-tailed t tests.
SAP Spec (analysed) Binding (binding) of associated with cytokine
18) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.91 Pain Relevance 0.28
We show that SAP binds to different strains of S. pneumoniae, and that this leads to activation of an important component of the immune response called the complement system.
SAP Binding (binds) of associated with sprains and strains
19) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1971117 Disease Relevance 1.01 Pain Relevance 0.03
Complement deposition, phagocytosis, and control of S. pneumoniae pneumonia were all improved by complementation with human SAP.
SAP Binding (complementation) of associated with pneumonia
20) Confidence 0.32 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1971117 Disease Relevance 0.90 Pain Relevance 0.05

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