INT212527

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PROC, Crp) peptidase activity (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
macrophages 1
PROC (Homo sapiens)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 78 99.82 Very High Very High Very High
Sprains And Strains 88 92.52 High High
Meningitis 2 66.20 Quite High
Sepsis 6 65.60 Quite High
Pneumonia 32 63.88 Quite High
Bacterial Infection 4 61.68 Quite High
Death 2 60.60 Quite High
Bacterial Meningitis 8 58.36 Quite High
Disease 8 53.76 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 52.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the presence of PC inhibited binding of both SAP and CRP (used as a positive control, as CRP is known to bind to S. pneumoniae cell wall PC) to a similar degree, suggesting that PC is a major ligand for SAP binding to S. pneumoniae (Figure 1D and 1E).
PC Binding (bind) of CRP
1) Confidence 0.00 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.59 Pain Relevance 0
The mechanisms by which the classical pathway is activated by S. pneumoniae infection include recognition of PC on the bacterial surface by natural IgM and CRP [34,37–40], and binding of bacterial capsular polysaccharide to the lectin SIGN-R1 expressed on marginal zone macrophages within the spleen [41].
PC Binding (recognition) of CRP in macrophages associated with infection
2) Confidence 0.00 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.92 Pain Relevance 0

General Comments

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