INT212527

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.50 Pain Relevance 0

extracellular space (PROC, Crp) peptidase activity (PROC) extracellular region (PROC) plasma membrane (PROC)

Anatomy Link Frequency macrophages 1 PROC (Homo sapiens) Crp (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 40 5.00 Inflammatory response 16 5.00 cytokine 14 5.00 chemokine 2 5.00 anesthesia 2 5.00 cva 2 5.00 halothane 2 5.00

Disease Link Frequency Relevance Heat Infection 78 99.82 Sprains And Strains 88 92.52 Meningitis 2 66.20 Sepsis 6 65.60 Pneumonia 32 63.88 Bacterial Infection 4 61.68 Death 2 60.60 Bacterial Meningitis 8 58.36 Disease 8 53.76 Acquired Immune Deficiency Syndrome Or Hiv Infection 10 52.44

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, the presence of PC inhibited binding of both SAP and CRP (used as a positive control, as CRP is known to bind to S. pneumoniae cell wall PC) to a similar degree, suggesting that PC is a major ligand for SAP binding to S. pneumoniae (Figure 1D and 1E).

PC Binding (bind) of CRP

1) Confidence 0.00 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.59 Pain Relevance 0

The mechanisms by which the classical pathway is activated by S. pneumoniae infection include recognition of PC on the bacterial surface by natural IgM and CRP [34,37–40], and binding of bacterial capsular polysaccharide to the lectin SIGN-R1 expressed on marginal zone macrophages within the spleen [41].

PC Binding (recognition) of CRP in macrophages associated with infection

2) Confidence 0.00 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.92 Pain Relevance 0

General Comments

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