INT212536

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.53
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL3A1) extracellular region (COL3A1)
COL3A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 92.48 High High
cva 7 80.00 Quite High
Pain 7 54.44 Quite High
imagery 3 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ehlers-danlos Syndrome 66 99.52 Very High Very High Very High
Heart Failure 2 98.70 Very High Very High Very High
Sudden Death 1 98.64 Very High Very High Very High
Rupture 9 96.76 Very High Very High Very High
Syndrome 64 95.16 Very High Very High Very High
Stroke 2 94.32 High High
Tinnitus 1 93.92 High High
Headache 1 92.48 High High
Contusions 1 91.28 High High
Ocular Toxicity (including Many Sub-types) 1 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EDS (vascular type) is due to a defect in COL3A1 therefore a diagnosis can be made if mutations are found in the type III collagen gene.
Negative_regulation (defect) of COL3A1 associated with ehlers-danlos syndrome
1) Confidence 0.57 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2628911 Disease Relevance 1.85 Pain Relevance 0.05
Carotid-cavernous fistulae (CCF) are another typical complication of EDS type IV [21,22] due to reduced content of collagen III in the arterial walls.
Negative_regulation (reduced) of collagen III associated with ehlers-danlos syndrome and heart failure
2) Confidence 0.43 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1971255 Disease Relevance 1.68 Pain Relevance 0.16

General Comments

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