INT21254

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.64
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
epidermis 4
plasma 2
T cells 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 11 100.00 Very High Very High Very High
dexamethasone 3 100.00 Very High Very High Very High
narcan 13 99.64 Very High Very High Very High
Dynorphin 2 99.08 Very High Very High Very High
analgesia 4 98.84 Very High Very High Very High
Migraine 3 98.60 Very High Very High Very High
headache 1 97.80 Very High Very High Very High
Pain 10 96.20 Very High Very High Very High
Opioid 10 95.20 Very High Very High Very High
rheumatoid arthritis 24 92.68 High High
Disease Link Frequency Relevance Heat
Disease 12 98.80 Very High Very High Very High
Headache 4 98.60 Very High Very High Very High
Stress 1 97.92 Very High Very High Very High
Pain 6 96.20 Very High Very High Very High
Addisons Disease 1 95.52 Very High Very High Very High
Skin Cancer 54 94.64 High High
Premature Aging 2 94.12 High High
Rheumatoid Arthritis 24 92.68 High High
INFLAMMATION 16 80.04 Quite High
Cushing's Syndrome /

Hypercortisolism

1 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone (2 mg/kg) had no effect on the dextrorphan-induced increases in plasma levels of ACTH and corticosterone, but it blocked the levorphanol-induced increases.
Neg (no) Regulation (effect) of Positive_regulation (increases) of ACTH in plasma associated with narcan
1) Confidence 0.61 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742749 Disease Relevance 0 Pain Relevance 0.52
In both species, staining for the prodynorphin (PRO-DYN) derivatives dynorphin A and alpha-neoendorphin or staining for the pro-opiomelanocortin (POMC)-derived beta-endorphin was not visualized.
Neg (not) Regulation (visualized) of Positive_regulation (-derived) of beta-endorphin associated with dynorphin
2) Confidence 0.45 Published 1989 Journal Prostate Section Abstract Doc Link 2734247 Disease Relevance 0 Pain Relevance 0.55
Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.
Regulation (Solar-simulated) of Positive_regulation (upregulation) of alpha-melanocyte-stimulating hormone in epidermis associated with melanocortin 1 receptor
3) Confidence 0.45 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.39 Pain Relevance 0.30
-MSH mediated induction of cytotoxicity in CD8+ T cells was dependent on melanocortin signaling via a functional MC-1R since ?
Regulation (dependent) of Positive_regulation (induction) of MSH in T cells
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.32 Pain Relevance 0
In both species, staining for the prodynorphin (PRO-DYN) derivatives dynorphin A and alpha-neoendorphin or staining for the pro-opiomelanocortin (POMC)-derived beta-endorphin was not visualized.
Neg (not) Regulation (visualized) of Positive_regulation (-derived) of pro-opiomelanocortin associated with dynorphin
5) Confidence 0.39 Published 1989 Journal Prostate Section Abstract Doc Link 2734247 Disease Relevance 0 Pain Relevance 0.55
Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.
Regulation (Solar-simulated) of Positive_regulation (upregulation) of proopiomelanocortin in epidermis associated with melanocortin 1 receptor
6) Confidence 0.39 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.38 Pain Relevance 0.29
The effect of dexamethasone on exercise-induced adrenocorticotropin (ACTH) secretion and dental analgesia was studied in healthy human subjects.
Regulation (effect) of Positive_regulation (induced) of adrenocorticotropin associated with dexamethasone and analgesia
7) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 2168784 Disease Relevance 0.23 Pain Relevance 0.53
Central serotonergic pathways are hypothesized to be involved in the stimulation of hypothalamic adrenocorticotropic hormone (ACTH) secretagogue release by both circadian- and stress-induced mechanisms.
Regulation (involved) of Positive_regulation (stimulation) of hypothalamic adrenocorticotropic hormone associated with stress
8) Confidence 0.24 Published 1997 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9171947 Disease Relevance 0.10 Pain Relevance 0.61
Moreover, FK 33--824 failed to influence the vasopressin-induced ACTH increase in 5 patients with Cushing's disease.
Neg (failed) Regulation (influence) of Positive_regulation (increase) of ACTH associated with disease
9) Confidence 0.23 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6281297 Disease Relevance 0.85 Pain Relevance 0.18
We observed the effect of a 5-day treatment with salmon calcitonin (IM 100 IU/day) on circulating levels of beta-endorphin, ACTH, and cortisol in 20 patients with migraine during the headache-free period.
Regulation (effect) of Positive_regulation (levels) of ACTH associated with migraine and headache
10) Confidence 0.19 Published 1989 Journal Biomed. Pharmacother. Section Abstract Doc Link 2560408 Disease Relevance 0.46 Pain Relevance 0.56
This study aimed at evaluating the effects of a dynamic physical training programme on circulating levels of corticotropin-releasing hormone (CRH), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EP) after high-intensity training for 6 weeks (60 min twice a week) and after low-intensity training (home-training) for another 6 months in patients with rheumatoid arthritis (RA) and in healthy subjects.
Regulation (effects) of Positive_regulation (levels) of beta-lipotropin associated with rheumatoid arthritis
11) Confidence 0.16 Published 1994 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 7836027 Disease Relevance 0.38 Pain Relevance 0.27
This study aimed at evaluating the effects of a dynamic physical training programme on circulating levels of corticotropin-releasing hormone (CRH), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EP) after high-intensity training for 6 weeks (60 min twice a week) and after low-intensity training (home-training) for another 6 months in patients with rheumatoid arthritis (RA) and in healthy subjects.
Regulation (effects) of Positive_regulation (levels) of beta-LPH associated with rheumatoid arthritis
12) Confidence 0.16 Published 1994 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 7836027 Disease Relevance 0.43 Pain Relevance 0.32

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