INT21255

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.11
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slco1c1)
Anatomy Link Frequency
brain 2
plasma 1
endothelial cells 1
Slco1c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 3 99.56 Very High Very High Very High
Morphine 11 99.20 Very High Very High Very High
Spinal cord 28 95.28 Very High Very High Very High
Eae 21 91.56 High High
Opioid 6 90.20 High High
Peripheral nerve injury 26 86.64 High High
Inflammation 4 82.48 Quite High
Central nervous system 31 80.00 Quite High
c fibre 42 77.88 Quite High
isoflurane 2 77.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 44 99.52 Very High Very High Very High
INFLAMMATION 3 98.84 Very High Very High Very High
Pressure And Volume Under Development 78 97.12 Very High Very High Very High
Viral Meningitis 3 95.40 Very High Very High Very High
Meningitis 3 94.76 High High
Sepsis 138 94.64 High High
Death 2 92.96 High High
Hypoglycemia 6 92.28 High High
Injury 48 91.56 High High
Brain Injury 27 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that even before magnesium reaches the brain site it interacts with the endothelial cells forming the BBB and inhibits their activation [4,24,25].
BBB Binding (interacts) of in endothelial cells
1) Confidence 0.33 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.89 Pain Relevance 0
The exact mechanism of magnesium's beneficial effect on the integrity of the BBB is unclear.
BBB Binding (integrity) of
2) Confidence 0.25 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 1.35 Pain Relevance 0
Although this might have clinical significance, a contrary suggestion could be that increasing the integrity of the BBB might also have negative effects in terms of antibiotic emergence when the clinical situation is complicated with encephalitis or meningitis.
BBB Binding (integrity) of associated with meningitis and viral meningitis
3) Confidence 0.25 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.78 Pain Relevance 0
PURPOSE: To determine the roles of blood-brain barrier (BBB) transport and plasma protein binding in brain uptake of nonsteroidal anti-inflammatory drugs (NSAIDs)-ibuprofen, flurbiprofen, and indomethacin.
BBB Binding (binding) of in brain associated with inflammation and cinod
4) Confidence 0.13 Published 2006 Journal Pharm. Res. Section Abstract Doc Link 16715377 Disease Relevance 0.17 Pain Relevance 0.27
FK in older rats had no effect on [3H]DAGO binding suggesting that formation of the BBB is complete at this age.
BBB Binding (formation) of
5) Confidence 0.08 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2168820 Disease Relevance 0 Pain Relevance 0.57
Taken together, our results showed that chronic morphine treatment does not significantly alter BBB integrity or P-gp activity.
BBB Binding (integrity) of associated with morphine
6) Confidence 0.06 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.78
For such studies to be predictive of interactions at the human BBB, the plasma concentration of the P-gp inhibitor must be comparable with that observed in the clinic.
BBB Binding (interactions) of in plasma
7) Confidence 0.03 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16415090 Disease Relevance 0 Pain Relevance 0.12
Evans Blue binds to albumin in the circulation producing a molecular complex of sufficient molecular size that it does not cross the intact BSCB or BBB.
BBB Neg (not) Binding (cross) of
8) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 1.10 Pain Relevance 0.71
In this study, we have employed the anti-neoplastic agent bleomycin, a glycopeptide antibiotic which acts by induction of DNA strand breaks, applied through a targeted opening of the BBB to inhibit tumor formation in the rat brain.
BBB Binding (targeted) of in brain associated with cancer
9) Confidence 0.01 Published 2009 Journal J Neurooncol Section Body Doc Link PMC2773371 Disease Relevance 0.81 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox