INT212562

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.08
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Adrm1) plasma membrane (Adrm1) nucleus (Adrm1)
cytoplasm (Adrm1)
Anatomy Link Frequency
arm 15
body 1
Adrm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 87 89.44 High High
cerebral cortex 36 83.44 Quite High
Eae 97 81.96 Quite High
Inflammation 17 61.36 Quite High
Hippocampus 105 60.08 Quite High
cva 34 50.00 Quite Low
nMDA receptor 12 37.44 Quite Low
depression 34 10.60 Low Low
amygdala 76 5.00 Very Low Very Low Very Low
Anterior cingulate cortex 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 422 99.78 Very High Very High Very High
Stress 101 98.96 Very High Very High Very High
Coronary Artery Disease 50 93.72 High High
Attention Deficit Hyperactivity Disorder 41 90.72 High High
Cv Unclassified Under Development 14 89.64 High High
Urological Neuroanatomy 95 89.44 High High
Erectile Dysfunction 140 87.16 High High
Diabetes Mellitus 16 84.52 Quite High
INFLAMMATION 17 61.36 Quite High
Adhesions 6 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the introduction of the delay, controls continued to choose the CRF arm, but HPC lesioned rats switched their preference to the immediate PRF arm.
Positive_regulation (immediate) of arm in arm
1) Confidence 0.10 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.16 Pain Relevance 0
For example, Rawlins and colleagues trained rats with HPC aspiration lesions and controls on a task in which one arm of a Y maze was continually reinforced (CRF) and the other reinforced on only 25% of trials (partially reinforced arm – PRF).
Positive_regulation (reinforced) of arm in arm
2) Confidence 0.10 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.06 Pain Relevance 0
In contrast, the cHPC lesion group showed an increased preference for the LR arm.
Positive_regulation (increased) of arm in arm
3) Confidence 0.10 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0.09
The partial lesion groups (dHPC and vHPC) also showed an increased preference for the LR arm but to a lesser extent than the cHPC group.
Positive_regulation (increased) of arm in arm
4) Confidence 0.10 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0.06
Both of these groups of rats continued to choose the HR arm, as in the previous, no-barrier condition, whereas both sham and vHPC rats shifted their behavior and increased their number of LR arm choices.
Positive_regulation (increased) of arm in arm
5) Confidence 0.10 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0
Initially introduced by Tolman (Tolman et al., 1946, 1947), this task requires to consistently reaching, the same goal arm of a T-maze from the same start arm, to get reward.
Positive_regulation (requires) of arm in arm
6) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2831625 Disease Relevance 0 Pain Relevance 0
In HA OVX rats, the open arm time and open arm activity were increased (both p values < 0.01) and the enclosed arm time and enclosed arm activity decreased (both p values < 0.05) after treatment with 750 mg/kg/day compared to before treatment.
Positive_regulation (increased) of arm in arm associated with anxiety disorder
7) Confidence 0.04 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.80 Pain Relevance 0.06
In HA OVX rats, the open arm time and open arm activity were increased (both p values < 0.01) and the enclosed arm time and enclosed arm activity decreased (both p values < 0.05) after treatment with 750 mg/kg/day compared to before treatment.
Positive_regulation (increased) of arm in arm associated with anxiety disorder
8) Confidence 0.04 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.80 Pain Relevance 0.06
Rats entering the same arm as that during training, therefore reaching the usually baited arm, were designated place learners.
Positive_regulation (reaching) of arm in arm
9) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2831625 Disease Relevance 0 Pain Relevance 0
From the usual start point, the task was identical to the initial task, but when rats started from the north point, half were required to use a place strategy (i.e. always reaching the same physical goal arm), while the other half were required to use a response strategy (i.e. always providing the same body turn).
Positive_regulation (reaching) of arm in body
10) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2831625 Disease Relevance 0 Pain Relevance 0
0.8 mg/L, P < 0.001 (Pearson's correlation coefficient 0.17, P = 0.13) in the atorvastatin arm; and ?
Positive_regulation (atorvastatin) of arm in arm
11) Confidence 0.03 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966969 Disease Relevance 0.35 Pain Relevance 0
more effective, increasing open arm avoidance over that seen in Handled CREB rats.
Positive_regulation (increasing) of arm in arm
12) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.55 Pain Relevance 0.08
Chronic administration of dioscorea at dosages of 750 and 1500 mg/kg/day, but not at 250 mg/kg/day, had an anxiolytic activity in HA OVX rats, increasing the open arm time and decreasing the enclosed arm time in the EPM test.
Neg (not) Positive_regulation (increasing) of arm in arm associated with anxiety disorder
13) Confidence 0.02 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.84 Pain Relevance 0.20
These subgroups (each of 34 rats) had the following profiles: The open arm time and open arm activity were significantly lower in HA rats than in LA rats (both p values < 0.001), while the enclosed arm time and enclosed arm activity were significantly higher than in LA rats (both p values < 0.05).
Positive_regulation (higher) of arm in arm associated with anxiety disorder
14) Confidence 0.02 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.81 Pain Relevance 0.04
Tadalafil was found to be significantly superior to placebo at both dosages for all primary efficacy end points; specifically, the mean IIEF-EF domain score increased by 4.8 and 4.5 points in the tadalafil 2.5 and 5 mg arms, respectively, relative to a 1.3 point increase in the placebo arm.
Positive_regulation (increase) of arm in arm
15) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.54 Pain Relevance 0.03
Tadalafil was found to be superior to placebo at both dosages for all primary efficacy end points; specifically, the mean IIEF-EF domain score increased by 6.1 and 7.0 points in the tadalafil 2.5 and 5 mg arms, respectively, relative to an increase of 1.2 points in the placebo arm.
Positive_regulation (increase) of arm in arm
16) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.17 Pain Relevance 0

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