INT212586

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 32 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 194 99.28 Very High Very High Very High
Coronary Heart Disease 1 98.66 Very High Very High Very High
Neuropathic Pain 1 98.28 Very High Very High Very High
Muscle Disease 1 98.04 Very High Very High Very High
Lactic Acidosis 2 97.84 Very High Very High Very High
Toxicity 22 97.42 Very High Very High Very High
Neutropenia 9 93.44 High High
Sprains And Strains 3 92.28 High High
Cytomegalovirus Infection 119 91.52 High High
Immunodeficiency 6 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Raltegravir was also >1000-fold more selective for HIV-1 integrase as compared with other phosphoryltransferases tested, including the polymerase and RNase H activities of HIV-1 reverse transcriptase and the human polymerases ?
Phosphorylation (phosphoryltransferases) of polymerase associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.61 Pain Relevance 0
The interaction can produce mitochondrial toxicity with lactic acidosis, myopathy, neuropathy and cardiomyopathy, all of which are presumably secondary to RBV-dependent increased phosphorylation of didanosine and mitochondrial DNA polymerase (polymerase-?)
Phosphorylation (phosphorylation) of polymerase associated with toxicity, lactic acidosis, neuropathic pain, muscle disease and coronary heart disease
2) Confidence 0.02 Published 2007 Journal Journal of Viral Hepatitis Section Body Doc Link PMC1974798 Disease Relevance 0.83 Pain Relevance 0
Following intracellular phosphorylation to the diphosphate form by host kinases, cidofovir targets the viral DNA polymerase by acting as a chain terminator.
Phosphorylation (phosphorylation) of polymerase
3) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861935 Disease Relevance 1.19 Pain Relevance 0

General Comments

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