INT21261

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Context Info
Confidence 0.02
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) plasma membrane (Npr1) intracellular (Npr1)
Penk (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
dopamine receptor 10 98.96 Very High Very High Very High
antagonist 8 97.40 Very High Very High Very High
Opioid 4 85.96 High High
mu opioid receptor 4 75.00 Quite High
Dopamine 2 75.00 Quite High
opioid receptor 2 73.84 Quite High
narcan 2 70.88 Quite High
Kappa opioid receptor 2 43.12 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
enkephalin Negative_regulation (reduced) of cyclase associated with agonist and enkephalin
1) Confidence 0.02 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 1.05
SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
enkephalin Negative_regulation (reduced) of cyclase associated with agonist and enkephalin
2) Confidence 0.02 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 0.96

General Comments

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