INT212655

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.57
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
brain 6
plasma 4
frontal cortex 3
prefrontal 1
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
electroacupuncture 182 99.98 Very High Very High Very High
amygdala 132 99.92 Very High Very High Very High
Inflammatory response 7 99.04 Very High Very High Very High
Glutamate 198 98.78 Very High Very High Very High
Inflammation 55 98.68 Very High Very High Very High
antidepressant 78 97.20 Very High Very High Very High
abdominal pain 9 94.64 High High
Somatosensory cortex 6 94.64 High High
spastic colon 51 92.16 High High
Thalamus 9 91.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 24 99.52 Very High Very High Very High
Stress 371 99.24 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

180 99.04 Very High Very High Very High
INFLAMMATION 64 98.68 Very High Very High Very High
Abdominal Pain 9 94.64 High High
Anxiety Disorder 48 93.88 High High
Pressure And Volume Under Development 36 92.24 High High
Congenital Anomalies 9 92.00 High High
Hyperalgesia 32 90.80 High High
Pain 22 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the present study provides evidence of increased brain activation, measured as increased MRI signal, in response to CRD in rats, following exposure of the amygdala to elevated levels of CORT for 7 days.
Positive_regulation (elevated) of Gene_expression (levels) of CORT in brain associated with amygdala
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.28
The current study demonstrates that, not only does luminal distension activate these structures in rodents, but also that CORT administration leads to a greater increase in the activation of these structures as well as the recruitment of other brain areas that were not activated in CHOL controls.
Positive_regulation (leads) of Gene_expression (administration) of CORT in brain
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.15 Pain Relevance 0.44
Here the levels of CORT were rapidly elevated in serum after FS-stress (Fig. 3A–B), whether rats were treated with antidepressants or not (F3,15?
Neg (not) Spec (whether) Positive_regulation (elevated) of Gene_expression (levels) of CORT associated with stress and antidepressant
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.68 Pain Relevance 0.51
Our results showed that there are significant differences in brain activation in rats in response to modulation of the amygdala via elevated levels of CORT.
Positive_regulation (elevated) of Gene_expression (levels) of CORT in brain associated with amygdala
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.35 Pain Relevance 0.58
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (increasing) of Gene_expression (levels) of CORT in frontal cortex associated with stress, glutamate and urological neuroanatomy
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.80 Pain Relevance 0.28
We also found that EA increased plasma CORT levels in inflamed rats but did not affect levels in naive rats.
Positive_regulation (increased) of Gene_expression (levels) of CORT in plasma associated with electroacupuncture
6) Confidence 0.33 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.79 Pain Relevance 0.80
We found that EA significantly increased plasma CORT levels in CFA-inflamed rats compared to sham EA.
Positive_regulation (increased) of Gene_expression (levels) of CORT in plasma associated with electroacupuncture
7) Confidence 0.33 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.77 Pain Relevance 1.05
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (increasing) of in prefrontal Gene_expression (levels) of CORT in frontal cortex associated with stress, glutamate and urological neuroanatomy
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.80 Pain Relevance 0.28

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