INT21276

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Context Info
Confidence 0.54
First Reported 1987
Last Reported 2005
Negated 0
Speculated 4
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 1.14
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 3
hypothalamus 1
striatum 1
M-1 1
medulla oblongata 1
Oprd1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 75 100.00 Very High Very High Very High
opioid receptor 26 100.00 Very High Very High Very High
Endogenous opioid 8 100.00 Very High Very High Very High
Delta opioid receptors 6 100.00 Very High Very High Very High
narcan 3 98.66 Very High Very High Very High
Opioid 3 98.60 Very High Very High Very High
medulla 8 97.76 Very High Very High Very High
Kappa opioid receptor 1 97.12 Very High Very High Very High
Intracerebroventricular 1 96.12 Very High Very High Very High
Antinociceptive 1 94.76 High High
Disease Link Frequency Relevance Heat
Hypertension 8 98.88 Very High Very High Very High
Cancer 1 80.96 Quite High
Death 2 80.52 Quite High
Cv Unclassified Under Development 3 80.04 Quite High
Hypoxia 1 72.88 Quite High
Urological Neuroanatomy 2 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the addition of a polycyclic ring to the C-terminal amino acid, the D-Ala2-D-Leu5-enkephalin-ellipticine conjugates bind to the opioid receptor from rat brain and NG 108-15 cells with an affinity constant close to 10(8) M-1.
opioid receptor Binding (bind) of enkephalin in M-1 associated with opioid receptor and enkephalin
1) Confidence 0.54 Published 1987 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2826357 Disease Relevance 0.08 Pain Relevance 0.43
Anti-idiotypic antibodies to anti-leucine enkephalin raised in rabbits immunized with leucine enkephalin conjugated to BSA, were purified and characterized for their ability to mimic leucine enkephalin in binding to the rat brain delta opioid receptor.
delta opioid receptor Binding (binding) of enkephalin in brain associated with opioid receptor and enkephalin
2) Confidence 0.27 Published 1993 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 8394838 Disease Relevance 0 Pain Relevance 0.51
Increased content of immunoreactive Leu-enkephalin and alteration of delta-opioid receptor in hearts of spontaneously hypertensive rats.
delta-opioid receptor Binding (alteration) of immunoreactive Leu-enkephalin in hearts associated with hypertension, opioid receptor and enkephalin
3) Confidence 0.26 Published 1988 Journal Neurosci. Lett. Section Title Doc Link 2853850 Disease Relevance 0.61 Pain Relevance 0.32
In the present study, we have further investigated whether opioid receptor interactions underlie the immunomodulatory effects of endogenous opioids as well as exogenously applied methionine-enkephalin (Met-Enk).
opioid receptor Binding (interactions) of enkephalin associated with endogenous opioid, enkephalin and opioid receptor
4) Confidence 0.26 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10996023 Disease Relevance 0 Pain Relevance 0.67
In the present study, we have further investigated whether opioid receptor interactions underlie the immunomodulatory effects of endogenous opioids as well as exogenously applied methionine-enkephalin (Met-Enk).
opioid receptor Binding (interactions) of Enk associated with endogenous opioid, enkephalin and opioid receptor
5) Confidence 0.26 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10996023 Disease Relevance 0 Pain Relevance 0.67
We performed an autoradiographic study of [D-Ala(2),MePhe(4),Gly-ol(5)]enkephalin (DAMGO)-sensitive [(3)H]naloxone binding to micro-opioid receptors and of [(3)H][D-Pen(2),D-Pen(5)]enkephalin (DPDPE) binding to delta-opioid receptors in the rat brain after 4- or 21-day treatments with paroxetine, reboxetine and moclobemide to investigate the participation of these receptors in the adaptive mechanisms occurring during the delay of action of new generation antidepressants.
delta-opioid Binding (binding) of enkephalin in brain associated with antidepressant, narcan, delta opioid receptors, opioid receptor and enkephalin
6) Confidence 0.18 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044796 Disease Relevance 0 Pain Relevance 0.68
Changes in activity of basic components of enkephalinergic system, leu-enkephalin contents, activity of enkephalin-hydrolysing enzymes (enkephalinases A and B, enkephalin aminopeptidases) and 3H-leu-enkephalin specific binding to opioid receptor in rat anterior and mediobasal hypothalamus, striatum, medulla oblongata and adenohypophysis have been analysed on experimental models of hypocorticoidism.
opioid receptor Spec (analysed) Binding (binding) of 3H-leu-enkephalin in adenohypophysis associated with medulla, opioid receptor and enkephalin
7) Confidence 0.16 Published 1995 Journal Fiziol Zh Section Abstract Doc Link 9026395 Disease Relevance 0 Pain Relevance 0.75
Changes in activity of basic components of enkephalinergic system, leu-enkephalin contents, activity of enkephalin-hydrolysing enzymes (enkephalinases A and B, enkephalin aminopeptidases) and 3H-leu-enkephalin specific binding to opioid receptor in rat anterior and mediobasal hypothalamus, striatum, medulla oblongata and adenohypophysis have been analysed on experimental models of hypocorticoidism.
opioid receptor Spec (analysed) Binding (binding) of 3H-leu-enkephalin in medulla oblongata associated with medulla, opioid receptor and enkephalin
8) Confidence 0.05 Published 1995 Journal Fiziol Zh Section Abstract Doc Link 9026395 Disease Relevance 0 Pain Relevance 0.75
Changes in activity of basic components of enkephalinergic system, leu-enkephalin contents, activity of enkephalin-hydrolysing enzymes (enkephalinases A and B, enkephalin aminopeptidases) and 3H-leu-enkephalin specific binding to opioid receptor in rat anterior and mediobasal hypothalamus, striatum, medulla oblongata and adenohypophysis have been analysed on experimental models of hypocorticoidism.
opioid receptor Spec (analysed) Binding (binding) of 3H-leu-enkephalin in hypothalamus associated with medulla, opioid receptor and enkephalin
9) Confidence 0.05 Published 1995 Journal Fiziol Zh Section Abstract Doc Link 9026395 Disease Relevance 0 Pain Relevance 0.75
Changes in activity of basic components of enkephalinergic system, leu-enkephalin contents, activity of enkephalin-hydrolysing enzymes (enkephalinases A and B, enkephalin aminopeptidases) and 3H-leu-enkephalin specific binding to opioid receptor in rat anterior and mediobasal hypothalamus, striatum, medulla oblongata and adenohypophysis have been analysed on experimental models of hypocorticoidism.
opioid receptor Spec (analysed) Binding (binding) of 3H-leu-enkephalin in striatum associated with medulla, opioid receptor and enkephalin
10) Confidence 0.05 Published 1995 Journal Fiziol Zh Section Abstract Doc Link 9026395 Disease Relevance 0 Pain Relevance 0.75
The compound (100 microM) significantly decreased the specific binding of [3H]D-Ala2, N-Me-Phe4, Gly5-ol-enkephalin (DAMGO) and [3H]D-Pen2, D-Pen5-enkephalin (DPDPE) at the mu- and delta-opioid receptor, respectively, but has no effect on the binding of [3H]U-69,593 at the kappa-opioid receptor of rat brain slices.
delta-opioid receptor Binding (binding) of D-Pen5-enkephalin in brain associated with kappa opioid receptor, opioid receptor and enkephalin
11) Confidence 0.02 Published 2005 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 18426082 Disease Relevance 0 Pain Relevance 0.47
These data suggest that one or more proenkephalin products interact with delta-opioid receptors to endogenously trigger opioid-mediated protection.
delta-opioid Binding (interact) of proenkephalin associated with delta opioid receptors and opioid
12) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10600867 Disease Relevance 0.45 Pain Relevance 1.29
Opioid receptor affinities ENK-S'8 and ENK-P8 were similar to [Leu]enkephalinamide, indicating that the connection of hydrophilic peptide segments to the C-terminal of [Leu]enkephalinamide did not affect the receptor affinity.
Opioid receptor Binding (affinities) of ENK-P8 associated with opioid receptor
13) Confidence 0.00 Published 1990 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2169466 Disease Relevance 0 Pain Relevance 0.24

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