INT212761

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SQLE) oxidoreductase activity (SQLE) endoplasmic reticulum (SQLE)
SQLE (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 96.32 Very High Very High Very High
adenocard 1 95.28 Very High Very High Very High
gABA 2 94.36 High High
sodium channel 1 85.88 High High
Arthritis 1 79.20 Quite High
imagery 1 77.08 Quite High
Inflammation 29 5.00 Very Low Very Low Very Low
Abeta 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 24 98.12 Very High Very High Very High
Cancer 82 95.88 Very High Very High Very High
Apoptosis 4 90.80 High High
Arthritis 1 79.20 Quite High
Increased Venous Pressure Under Development 1 78.64 Quite High
Colon Cancer 1 74.48 Quite High
Skin Cancer 1 46.32 Quite Low
Carcinoma 1 35.20 Quite Low
Lobular Carcinoma 1 9.00 Low Low
INFLAMMATION 29 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only C8orf53, MAL2, LOC286052, SQLE and KIAA0196 were upregulated in proportion to copy number gain or amplification of the 8q23.3-q24.21 region in the ERBB2-amplified tumors.
Regulation (upregulated) of SQLE associated with cancer
1) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.80 Pain Relevance 0
The randomly chosen drug targets were not skewed towards peptide receptors and included: squalene epoxidase, RAF proto-oncogene serine/threonine-protein kinase, muscarinic acetylcholine receptor M4, opioid mu receptor (OP3), adenosine A1 receptor, GABA transaminase, amidophosphoribosyltransferase precursor, tryptophan 5-hydroxylase 1, apoptosis regulator Bcl-2, matrix protein M2, vascular endothelial growth factor receptor 2 precursor, amiloride-sensitive sodium channel gamma-subunit, ribonucleotide reductase, cAMP phosphodiesterase, coagulation factor VIII, high affinity immunoglobulin epsilon receptor alpha-subunit precursor, retinol-binding protein I, glycine alpha 2 receptor, cytochrome P450 51, GABA-A receptor subunit (C. elegans).
Regulation (targets) of squalene epoxidase associated with gaba, adenocard, sodium channel, apoptosis and opioid
2) Confidence 0.02 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1976427 Disease Relevance 0.41 Pain Relevance 0.35

General Comments

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