INT212790

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.04
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) response to stress (C5)
C5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 62 99.36 Very High Very High Very High
Inflammation 41 98.68 Very High Very High Very High
antagonist 12 89.56 High High
rheumatoid arthritis 308 89.04 High High
cytokine 5 85.04 High High
depression 2 66.80 Quite High
medulla 5 30.96 Quite Low
Analgesic 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 179 100.00 Very High Very High Very High
Arthritis 58 99.36 Very High Very High Very High
INFLAMMATION 44 98.68 Very High Very High Very High
Disease 146 98.16 Very High Very High Very High
Aspiration Pneumonia 47 97.32 Very High Very High Very High
Rheumatoid Arthritis 312 89.04 High High
Necrosis 4 86.00 High High
Cancer 4 85.64 High High
Depression 2 66.80 Quite High
Pneumonia 11 51.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore likely that although the primary function of the complement system is to protect the host from microorganisms, a deregulated activity of its central component, C5, can play a substantial role in inflammatory diseases as well.
Regulation (deregulated) of C5 associated with inflammation and disease
1) Confidence 0.24 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.68 Pain Relevance 0.25
We hypothesize that this putative transcription factor binding site may be involved in the regulation of the neighboring TRAF1 and/or C5 gene.


Regulation (regulation) of C5
2) Confidence 0.24 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.48 Pain Relevance 0.18
In the present study, C2 and C5 are same value in 1 subject in control group and 5 subjects in the patients with aspiration pneumonia.


Regulation (value) of C5 associated with cough and aspiration pneumonia
3) Confidence 0.22 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 2.61 Pain Relevance 0.03
In this respect, a prominent role for the complement system has been identified as mice deficient in complement factors are resistant to arthritis, and as it has been shown that targeting complement component 5 (C5) by antibodies prevents the onset of arthritis and reduces the clinical severity in mouse models for arthritis [7,8].
Regulation (targeting) of C5 associated with arthritis
4) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 1.13 Pain Relevance 0.52
In this respect, a prominent role for the complement system has been identified as mice deficient in complement factors are resistant to arthritis, and as it has been shown that targeting complement component 5 (C5) by antibodies prevents the onset of arthritis and reduces the clinical severity in mouse models for arthritis [7,8].
Regulation (targeting) of complement component 5 associated with arthritis
5) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 1.13 Pain Relevance 0.52
Dark areas indicate controlFig. 2Cell proliferation induced by C5a. [3H]-thymidine incorporation was measured with a liquid scintillation counter 48 h after adding the various concentrations of C5a, C5, or C3a to the HMEC-1 suspension. a C5a increased HMEC-1 proliferation in a dose-dependent manner, whereas C5 (b) and C3a (c) did not induce proliferation. d HMEC-1 was stimulated with either 10 nM C5a in the presence of various concentrations of C5a receptor antagonist W-54011 (closed column) or W-54011 alone (open column).
Regulation (concentrations) of C5 associated with antagonist
6) Confidence 0.10 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0 Pain Relevance 0.09

General Comments

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