INT212813

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Nos2) intracellular (Tlr4, Nos2) cytoplasm (Tlr4, Nos2)
cytosol (Nos2) extracellular space (Nos2) oxidoreductase activity (Nos2)
Tlr4 (Mus musculus)
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 55 94.84 High High
Inflammation 65 90.92 High High
Inflammatory mediators 5 36.56 Quite Low
Inflammatory response 10 14.64 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 85 90.92 High High
Disease 5 88.84 High High
Infection 4 68.68 Quite High
Cancer 8 60.24 Quite High
Death 4 39.92 Quite Low
Necrosis 6 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Sepsis 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Hepatotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In response to LPS, COX-2-/- mice showed a higher increase in iNOS mRNA levels compared to COX-2+/+ mice (Fig. 5A).
LPS Positive_regulation (increase) of iNOS
1) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.09 Pain Relevance 0.05
The iNOS protein was strongly induced by LPS.
LPS Positive_regulation (induced) of iNOS protein
2) Confidence 0.03 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC1978242 Disease Relevance 0.05 Pain Relevance 0.10
and IL-6, and the expression of iNOS and COX-2 activated by LPS.
LPS Positive_regulation (activated) of iNOS
3) Confidence 0.01 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC1978242 Disease Relevance 0.74 Pain Relevance 0.43

General Comments

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