INT212818

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm5) plasma membrane (Chrm5) signal transducer activity (Chrm5)
Chrm5 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 185 97.20 Very High Very High Very High
alcohol 76 96.80 Very High Very High Very High
cannabis 72 96.16 Very High Very High Very High
dopamine receptor 8 82.40 Quite High
antagonist 3 74.88 Quite High
Dopamine 61 66.28 Quite High
Eae 1 58.24 Quite High
cocaine 24 52.68 Quite High
Morphine 14 52.20 Quite High
withdrawal 24 51.32 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 17 99.08 Very High Very High Very High
Alcohol Addiction 21 97.20 Very High Very High Very High
Targeted Disruption 57 91.40 High High
Cannabis Dependence 27 90.00 High High
Drug Dependence 28 73.56 Quite High
Infection 33 54.72 Quite High
Aggression 2 33.28 Quite Low
Mental Disorders 3 10.24 Low Low
Nicotine Addiction 57 5.00 Very Low Very Low Very Low
Encephalitis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association between substance use behaviour and CHRM5 was investigated using longitudinal data from a population-based cohort of an initial potential sample of 2032 adolescents in Victoria, Australia.
CHRM5 Binding (Association) of
1) Confidence 0.35 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.07 Pain Relevance 0.19
This is the first study to show an association between CHRM5 and substance use in humans.
CHRM5 Binding (association) of
2) Confidence 0.35 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0.26 Pain Relevance 0.48
Consequently, the linkage of the CHRM5-CHRNA7 haplotype with schizophrenia is unlikely to represent evidence due to linkage disequilibrium with functional markers in either gene.


CHRM5 Binding (linkage) of associated with schizophrenia
3) Confidence 0.35 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.65 Pain Relevance 0.32
Both cholinergic and dopaminergic systems are involved in the USVs elicited during male-female interactions, with M2 and M5 muscarinic receptors particularly important in the induction.
M5 Binding (interactions) of
4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.31 Pain Relevance 0.15
Initially, we tried combinations of P-2, M-5 and M-6 siRNAs at different concentrations (10, 25, 50, 100 and 200pmol of each siRNA) against 36, 18 and 3.6 PFU/ml.
M-5 Binding (combinations) of
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.05 Pain Relevance 0

General Comments

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