INT212819

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 0
Speculated 4
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.64
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm5) plasma membrane (Chrm5) signal transducer activity (Chrm5)
Anatomy Link Frequency
brain 1
Chrm5 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 189 100.00 Very High Very High Very High
dopamine receptor 24 98.68 Very High Very High Very High
cocaine 24 98.52 Very High Very High Very High
alcohol 78 98.16 Very High Very High Very High
Morphine 18 97.88 Very High Very High Very High
Dopamine 105 97.84 Very High Very High Very High
cannabis 72 97.68 Very High Very High Very High
withdrawal 24 96.72 Very High Very High Very High
opiate 18 95.96 Very High Very High Very High
Nucleus accumbens 6 89.68 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 156 99.72 Very High Very High Very High
Sprains And Strains 12 95.92 Very High Very High Very High
Alcohol Addiction 21 68.12 Quite High
Cannabis Dependence 27 58.08 Quite High
Confusion 3 50.64 Quite High
Cognitive Disorder 12 27.12 Quite Low
Nicotine Addiction 57 16.24 Low Low
Aggression 6 12.28 Low Low
Drug Dependence 30 5.00 Very Low Very Low Very Low
Schizophrenia 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the role of variation in the CHRM5 gene and dependence on three drugs of addiction, namely tobacco, alcohol and cannabis.
Spec (examined) Regulation (role) of CHRM5 associated with addiction, cannabis and alcohol
1) Confidence 0.44 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.13 Pain Relevance 0.81
We examined the role of variation in the CHRM5 gene and dependence on three drugs of addiction, namely tobacco, alcohol and cannabis.
Spec (examined) Regulation (dependence) of CHRM5 associated with addiction, cannabis and alcohol
2) Confidence 0.44 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.12 Pain Relevance 0.80
To investigate the effects of the M5 receptor in USV production, we studied USVs during male-female interaction using M5 KO mice (CD1x129 strain).
Spec (investigate) Regulation (effects) of M5 associated with targeted disruption and sprains and strains
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.49 Pain Relevance 0.19
We acknowledge that our approach and chosen screening region cannot account for the influence of long-range regulatory elements or that of epigenetic modifications that alter the function of the CHRM5 gene.
Regulation (alter) of CHRM5
4) Confidence 0.27 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.29
Furthermore, given the effects of M2, M4, M5 muscarinic receptors and the D2 dopamine receptor in dopamine release [23]–[25], [66], and their varied and wide distribution in the brain [28], [29], we postulate that, these receptors are more likely to contribute to the regulation of emotion and motivation.
Spec (postulate) Regulation (effects) of M5 in brain associated with dopamine and dopamine receptor
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.33 Pain Relevance 0.13
By studying knockout mice, we further found that: 1) USVs were lost in about 75% of M2 KO mice, associated with a loss of sexual interaction. 2) In M5 KO mice, frequency-modulated USVs from male mice were reduced by almost 80%. 3) USVs were not altered reliably in M4 KO mice. 4) M2, M5 and D2 receptors played a role in either duration or peak or bandwidth of USVs.
Regulation (played) of M5 associated with targeted disruption
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.57 Pain Relevance 0

General Comments

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