INT212821

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.25
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
oocytes 1
Sugt1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 134 98.44 Very High Very High Very High
cannabis 48 98.00 Very High Very High Very High
Neuropathic pain 1 86.12 High High
potassium channel 1 79.84 Quite High
Hippocampus 14 74.08 Quite High
alcohol 58 73.20 Quite High
cocaine 33 72.40 Quite High
Morphine 21 71.92 Quite High
withdrawal 33 71.04 Quite High
Dopamine 26 67.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 40 100.00 Very High Very High Very High
Cannabis Dependence 18 98.44 Very High Very High Very High
Drug Dependence 22 91.48 High High
Neuropathic Pain 1 86.12 High High
Sprains And Strains 126 84.32 Quite High
Alcohol Addiction 17 73.20 Quite High
Diphtheria 3 64.24 Quite High
Hyperphagia 24 50.00 Quite Low
Nicotine Addiction 38 43.68 Quite Low
Syndrome 88 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the expanded RI set, the D2 allele is the allele with the higher effect and consequently results in a non-significant QTL (Fig. 3).


Positive_regulation (results) of allele
1) Confidence 0.02 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.09 Pain Relevance 0.16
To derive 2-loxP mice, 2-loxP ES cells were injected into C57Bl/6J –Tyrc-2J/J albino blastocysts and three male chimeric mice were obtained, with 20–80% ES cell origin based on coat color, all of which transmitted the modified allele through the germ-line.
Positive_regulation (modified) of allele
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.25 Pain Relevance 0
We observed a 26.8% increase in cigarette consumption in carriers of the T-allele, equating to 20.1 cigarettes per week (nominal p = 0.01).
Positive_regulation (increase) of T-allele
3) Confidence 0.01 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.23 Pain Relevance 0.52
We observed a 26.8% increase in cigarette consumption in carriers of the rs7162140 T-allele, equating to 20.1 cigarettes per week (p=0.01).
Positive_regulation (increase) of T-allele
4) Confidence 0.01 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0.25 Pain Relevance 0.66
To generate the Cre-deleted knockout allele (KO), males containing one or two Conditional Alleles (CA) were bred with females expressing Cre recombinase in their oocytes from a ZP3-Cre transgene [35].
Positive_regulation (generate) of allele in oocytes associated with targeted disruption
5) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.43 Pain Relevance 0

General Comments

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