INT212822

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.86
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm5) plasma membrane (Chrm5) signal transducer activity (Chrm5)
Anatomy Link Frequency
forebrain 1
Chrm5 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 248 99.72 Very High Very High Very High
midbrain 6 99.32 Very High Very High Very High
Dopamine 96 99.08 Very High Very High Very High
withdrawal 32 99.00 Very High Very High Very High
Morphine 20 97.76 Very High Very High Very High
cocaine 32 97.08 Very High Very High Very High
alcohol 102 90.08 High High
cannabis 96 89.12 High High
dopamine receptor 16 85.60 High High
opiate 18 81.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 108 99.96 Very High Very High Very High
Drug Dependence 38 99.72 Very High Very High Very High
Psychosis 2 80.60 Quite High
Alcohol Addiction 28 73.76 Quite High
Cannabis Dependence 36 63.72 Quite High
Morphine Dependence 2 49.76 Quite Low
Nicotine Addiction 76 48.80 Quite Low
Aggression 4 18.24 Low Low
Cognitive Disorder 8 15.08 Low Low
Schizophrenia 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, mice lacking a functional M5R were shown to have reduced reward and withdrawal responses following morphine [8] and cocaine [9] administration.
Negative_regulation (lacking) of M5R associated with withdrawal, cocaine and morphine
1) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.42
Mice lacking a functional M5R were shown to have reduced reward and withdrawal responses following morphine [8] and cocaine [9] administration.
Negative_regulation (lacking) of M5R associated with withdrawal, cocaine and morphine
2) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.10 Pain Relevance 1.00
Studies on rats deficient in M5R have shown that midbrain M5R mediate the duration of forebrain dopamine transmission and the maintenance of dopamine-related reward [6,7].
Negative_regulation (deficient) of M5R in forebrain associated with dopamine and midbrain
3) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.37
Mice lacking a functional M5R have reduced reward and withdrawal responses following morphine [8] and cocaine [9] administration.
Negative_regulation (lacking) of M5R associated with withdrawal, cocaine and morphine
4) Confidence 0.37 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.14 Pain Relevance 0.80
In this study, we found the USV quality was still excellent in M2, M4, M5 muscarinic and the D2 receptors KO mice, implying that motor control in the KO mice is not defective.
Negative_regulation (excellent) of M5 associated with targeted disruption
5) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.34 Pain Relevance 0.12
The dramatic reduction of USVs in M2 and M5 KO mice during male-female interactions suggested that both M2 and M5 receptors were crucial for USVs associated with male-female interactions.
Negative_regulation (reduction) of M5 associated with targeted disruption
6) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.28 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox