INT212845

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1) intracellular (DR1) DNA binding (DR1)
transcription factor binding (DR1)
DR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 95.36 Very High Very High Very High
Arthritis 3 76.48 Quite High
Inflammation 9 66.88 Quite High
metalloproteinase 14 50.00 Quite Low
agonist 1 50.00 Quite Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 5 76.48 Quite High
Arthropathy 2 75.28 Quite High
Sprains And Strains 30 69.20 Quite High
INFLAMMATION 10 66.88 Quite High
Chondrosarcoma 6 61.68 Quite High
Francisella Infection 25 50.00 Quite Low
Disease 6 8.88 Low Low
Syndrome 6 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DR1 and DR3 are likewise reversed in orientation relative to the sequences in Schu S4.
Negative_regulation (reversed) of DR1
1) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1978527 Disease Relevance 0.07 Pain Relevance 0
heterodimer to the DR-1 element precludes binding of AP-1 proteins to its site and thereby antagonizes the expression of MMP-1.
Negative_regulation (precludes) of DR-1 element
2) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.15

General Comments

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