INT2129

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 83
Total Number 86
Disease Relevance 58.95
Pain Relevance 12.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
platelet 15
plasma 6
blood 4
hepatocytes 3
chest 2
F2 (Homo sapiens)
F2 - G20210A (1)
Pain Link Frequency Relevance Heat
Paracetamol 18 99.82 Very High Very High Very High
analgesia 6 99.62 Very High Very High Very High
diclofenac 12 99.48 Very High Very High Very High
cytokine 291 99.46 Very High Very High Very High
epidural 5 99.42 Very High Very High Very High
spastic colon 29 99.36 Very High Very High Very High
Angina 64 99.28 Very High Very High Very High
Inflammation 427 99.26 Very High Very High Very High
antagonist 92 99.00 Very High Very High Very High
alcohol 24 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thrombocytopenia 19 99.96 Very High Very High Very High
Hemorrhage 172 99.92 Very High Very High Very High
Reperfusion Injury 9 99.90 Very High Very High Very High
Coagulation Disorder 157 99.82 Very High Very High Very High
Ataxia 3 99.82 Very High Very High Very High
Pressure And Volume Under Development 199 99.74 Very High Very High Very High
Hematuria 3 99.72 Very High Very High Very High
Disseminated Intravascular Coagulation 127 99.66 Very High Very High Very High
Jaundice 6 99.66 Very High Very High Very High
Diabetes Mellitus 236 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The only abnormality recorded was an elevated prothrombin time.
Positive_regulation (elevated) of prothrombin
1) Confidence 0.70 Published 1976 Journal Arch Surg Section Abstract Doc Link 1267616 Disease Relevance 0.63 Pain Relevance 0.09
The slight increase in prothrombin time seen when diflunisal and acenocoumarol were co-administered is not considered to be of major clinical importance.
Positive_regulation (increase) of prothrombin
2) Confidence 0.70 Published 1978 Journal Curr Med Res Opin Section Abstract Doc Link 359244 Disease Relevance 0.09 Pain Relevance 0.12
However one patient who received the highest dose of 100 mg cisplatin developed a persistent but reversible clinical jaundice and a transient increase in prothrombin time.
Positive_regulation (increase) of prothrombin associated with jaundice
3) Confidence 0.70 Published 2001 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 11484972 Disease Relevance 0.91 Pain Relevance 0.08
This condition develops as the result of the formation of antibodies to the heparin-platelet factor 4 complex, which causes secondary activation of platelets, coagulation, and ultimately increased thrombin production.33
Positive_regulation (increased) of thrombin in platelets
4) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 1.01 Pain Relevance 0.04
In addition, activated prothrombin complex concentrates and recombinant activated factor VII were intravenously administered which successfully controlled his hemorrhage.
Positive_regulation (activated) of prothrombin associated with cva
5) Confidence 0.52 Published 2006 Journal Rinsho Ketsueki Section Abstract Doc Link 16715966 Disease Relevance 1.26 Pain Relevance 0.17
Non-activated and activated prothrombin complex concentrates have been used successfully to treat bleeds in haemophilia patients with inhibitors, but most physicians do not consider these products as effective as factor VIII/IX concentrates in non-inhibitor patients.
Positive_regulation (activated) of prothrombin associated with coagulation disorder
6) Confidence 0.50 Published 2004 Journal Haemophilia Section Abstract Doc Link 15385045 Disease Relevance 0.22 Pain Relevance 0
Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX: the updated Norwegian experience.
Positive_regulation (Activated) of prothrombin
7) Confidence 0.50 Published 2004 Journal Haemophilia Section Title Doc Link 15385045 Disease Relevance 0.36 Pain Relevance 0.11
Non-activated and activated prothrombin complex concentrates (PCC/aPCC) have been used successfully to treat bleeds in haemophilia patients with inhibitors, but most physicians do not consider these products as effective as factor VIII/IX (FVIII/IX) concentrates in non-inhibitor patients.
Positive_regulation (activated) of prothrombin associated with coagulation disorder
8) Confidence 0.50 Published 2004 Journal Haemophilia Section Abstract Doc Link 14962207 Disease Relevance 0.22 Pain Relevance 0
Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX.
Positive_regulation (Activated) of prothrombin
9) Confidence 0.50 Published 2004 Journal Haemophilia Section Title Doc Link 14962207 Disease Relevance 0.37 Pain Relevance 0.11
Postpartum seizures after epidural analgesia: a patient with a mutation of the factor V Leiden and prothrombin gene.
Positive_regulation (mutation) of prothrombin associated with convulsion, epidural, headache and analgesia
10) Confidence 0.49 Published 2007 Journal J Clin Anesth Section Title Doc Link 18063213 Disease Relevance 0.29 Pain Relevance 0.39
Further, increasing concentrations of thrombin overcame the inhibitory effect of the patient's paraprotein.
Positive_regulation (increasing) of thrombin
11) Confidence 0.48 Published 1987 Journal Am. J. Hematol. Section Abstract Doc Link 3578266 Disease Relevance 0.35 Pain Relevance 0.06
Transient increase of hepatic transaminases without change in prothrombin time was registered in all patients.
Positive_regulation (increase) of prothrombin
12) Confidence 0.47 Published 2001 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 11484972 Disease Relevance 1.01 Pain Relevance 0.09
Blood analysis was normal (including platelet count) except for the activated partial thromboplastin (PTT) and prothrombin (PT) time, which exceeded the laboratory limits of determination.
Neg (except) Positive_regulation (activated) of prothrombin in Blood
13) Confidence 0.46 Published 1999 Journal G Ital Cardiol Section Abstract Doc Link 10231678 Disease Relevance 0.91 Pain Relevance 0.29
Severe PPH was defined as a blood loss greater than 1500 cc and either haemodynamic shock (defined by the need for continuous perfusion of vasopressors) or disseminated intravascular coagulation (platelet count <50 000 per mm3, elevated prothrombin time, defined as greater than twice the control values, hypofibrinogenemia, defined as less than 150 mg/dl, and a prothrombin rate less than 50%), or both.
Positive_regulation (elevated) of prothrombin in platelet associated with pressure volume 2 under development, shock, cva and thrombosis
14) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2583949 Disease Relevance 0.96 Pain Relevance 0.26
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Positive_regulation (elevated) of prothrombin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
15) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.61 Pain Relevance 0.06
Heterozygous carriers of this mutation have elevated plasma prothrombin and are prone to venous thrombotic episodes [3].
Positive_regulation (elevated) of prothrombin in plasma
16) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868876 Disease Relevance 0.78 Pain Relevance 0.29
Heterozygotes for the variant have 30% increased plasma prothrombin levels [4,5].
Positive_regulation (increased) of prothrombin in plasma
17) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868876 Disease Relevance 0.91 Pain Relevance 0.04
He was asymptomatic but his prothrombin time was markedly elevated with an international normalized ratio (INR) of 37.8.
Positive_regulation (elevated) of prothrombin
18) Confidence 0.44 Published 2003 Journal Pharmacotherapy Section Abstract Doc Link 14524650 Disease Relevance 0.45 Pain Relevance 0.06
Laboratory abnormalities may include anemia, leukopenia, thrombocytopenia, increased AST/ALT levels, and prolonged prothrombin, bleeding, and activated partial thromboplastin times.
Spec (partial) Positive_regulation (increased) of prothrombin associated with anaemia, leukopenia, congenital anomalies, hemorrhage and thrombocytopenia
19) Confidence 0.41 Published 2007 Journal Arch Iran Med Section Abstract Doc Link 17367225 Disease Relevance 1.67 Pain Relevance 0.18
Blood samples for thrombin and platelet markers were centrifuged at 2,500g for 15 min, and plasma was stored at ?
Positive_regulation (samples) of thrombin in plasma
20) Confidence 0.41 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.40 Pain Relevance 0.06

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