INT212933

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 4 97.36 Very High Very High Very High
Bioavailability 6 92.52 High High
Inflammation 10 51.24 Quite High
tolerance 5 34.12 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 3 95.64 Very High Very High Very High
Diabetes Mellitus 23 94.60 High High
Stress 25 89.92 High High
Folic Acid Deficiency 2 84.64 Quite High
Obesity 13 72.96 Quite High
Increased Venous Pressure Under Development 76 55.56 Quite High
INFLAMMATION 11 51.24 Quite High
Hyperglycemia 4 49.88 Quite Low
Metabolic Syndrome 2 48.28 Quite Low
Impaired Glucose Tolerance 5 34.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another mechanism involves the uncoupling of eNOS as a result of diminished levels of the essential eNOS cofactor, tetrahydrobiopterin, resulting in enhanced O2??
Regulation (involves) of eNOS Binding (uncoupling) of associated with tetrahydrobiopterin
1) Confidence 0.34 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.56 Pain Relevance 0.16
The results of our study suggest that folic acid, by directly interacting with eNOS, directly modulates NO production and endothelial function, independently of established markers of endothelial dysfunction and cardiovascular disease in type 2 diabetes.
Regulation (modulates) of eNOS Binding (interacting) of associated with diabetes mellitus and cardiovascular disease
2) Confidence 0.05 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993928 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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