INT212959

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 7.70
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Scarb1) plasma membrane (Scarb1) cytoplasm (Scarb1)
Anatomy Link Frequency
macrophage 1
Scarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 91 98.64 Very High Very High Very High
cytokine 48 75.08 Quite High
Inflammation 126 74.72 Quite High
chemokine 2 58.28 Quite High
Bile 20 23.12 Low Low
lidocaine 16 5.00 Very Low Very Low Very Low
aspirin 15 5.00 Very Low Very Low Very Low
alcohol 14 5.00 Very Low Very Low Very Low
Angina 13 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1365 99.92 Very High Very High Very High
Adhesions 37 96.64 Very High Very High Very High
Infection 172 95.68 Very High Very High Very High
Mycobacterial Infection 408 95.60 Very High Very High Very High
Myocardial Infarction 88 95.60 Very High Very High Very High
Coronary Heart Disease 243 89.24 High High
Coronary Artery Disease 21 84.12 Quite High
Apoptosis 22 80.12 Quite High
Death 48 79.60 Quite High
INFLAMMATION 133 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrated that mycobacteria bound directly to SR-B1, and that this binding could be competitively inhibited by specific antibodies, lipids, serum and surfactant (Fig. 2A–E).
SR-B1 Binding (bound) of
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.05 Pain Relevance 0
Although SR-B1 is known to have broad ligand specificity [15], and recognizes various different lipoprotein classes, we chose unmodified LDL as this particle has shown to bind specifically to SR-B1 but not CD36 or class A scavenger receptors [16].
SR-B1 Binding (recognizes) of
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0 Pain Relevance 0
Although SR-B1 is known to have broad ligand specificity [15], and recognizes various different lipoprotein classes, we chose unmodified LDL as this particle has shown to bind specifically to SR-B1 but not CD36 or class A scavenger receptors [16].
SR-B1 Binding (bind) of
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0 Pain Relevance 0
Taken together, we demonstrate that SR-B1 is another example of the diverse spectrum of receptors that recognize mycobacteria in vitro but is redundant in the extremely complex macrophage-mycobacterium interaction in vivo.
SR-B1 Binding (interaction) of in macrophage
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.77 Pain Relevance 0
We show here that mycobacteria can bind directly to SR-B1 on transfected cells, and that this interaction could be inhibited in the presence of a specific antibody to SR-B1, serum or LDL.
SR-B1 Binding (bind) of
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794535 Disease Relevance 0.57 Pain Relevance 0.03
However, depletion of the membrane's cholesterol by cyclodextrins did not significantly reduce mycobacterial binding to SR-B1 expressing cells (Fig. 2F).
SR-B1 Binding (binding) of
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.12 Pain Relevance 0.03
However, binding of mycobacteria to both wild type and SR-B1?
SR-B1 Binding (binding) of
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0 Pain Relevance 0
Thus overall, these data suggest that SR-B1 can directly recognize mycobacteria and that this interaction can be inhibited by serum and surfactant components.


SR-B1 Binding (recognize) of
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.42 Pain Relevance 0
The mechanism of HDL-C mediated eNOS activation remains unknown, however may involve an interaction between endothelial SR-B1 and Apo AI (Yuhanna et al 2001).
SR-B1 Binding (interaction) of associated with disorder of lipid metabolism
9) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 2.01 Pain Relevance 0.16
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
scavenger receptor-BI Binding (binding) of associated with disorder of lipid metabolism
10) Confidence 0.16 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.14 Pain Relevance 0.12
These receptors include ATP-binding cassette transporter A-1 (ABCA-1), ATP-binding cassette transporter G-1 (ABCG-1), and scavenger receptor class-B type-1 (SR-B1.
SR-B1 Binding (binding) of
11) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0
These receptors include ATP-binding cassette transporter A-1 (ABCA-1), ATP-binding cassette transporter G-1 (ABCG-1), and scavenger receptor class-B type-1 (SR-B1.
scavenger receptor class-B type-1 Binding (binding) of
12) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0
These helical regions in the apolipoprotein of the HDL, apo A-1, similarly allows HDL to dock with the cell surface receptors ABCA-1 and SR-BI.
SR-BI Binding (dock) of associated with disorder of lipid metabolism
13) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.81 Pain Relevance 0.28
Recently, it was demonstrated that schistosome CD36-like class B scavenger receptor binds to host low density lipoproteins [39].
class B scavenger receptor Binding (binds) of
14) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 0.28 Pain Relevance 0

General Comments

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