INT21296

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Context Info
Confidence 0.03
First Reported 1990
Last Reported 1993
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.21
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Cenpf) chromosome segregation (Cenpf) nucleus (Cenpf)
transcription factor binding (Cenpf) cytoplasm (Cenpf)
Anatomy Link Frequency
LEK 2
plasma 1
artery 1
Cenpf (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 38 100.00 Very High Very High Very High
Clonidine 3 88.52 High High
Neuropeptide 2 75.00 Quite High
Endogenous opioid 3 68.96 Quite High
Disease Link Frequency Relevance Heat
Hypertension 30 100.00 Very High Very High Very High
Hypotension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma LEK and beta-EP levels in patients with essential hypertension increased after one month of captopril treatment.
Positive_regulation (increased) of LEK in LEK associated with hypertension and enkephalin
1) Confidence 0.03 Published 1990 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 2169983 Disease Relevance 0.67 Pain Relevance 1.00
After a single dose of captopril, blood pressure and plasma angiotensin II decreased, plasma renin activity increased; and plasma LEK and beta-EP levels increased.
Positive_regulation (increased) of LEK in plasma associated with enkephalin
2) Confidence 0.03 Published 1990 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 2169983 Disease Relevance 0.67 Pain Relevance 0.99
In conclusion, the lower plasma LEK and beta-EP levels in patients with essential hypertension indicate that LEK and beta-EP may play a role in the pathogenesis of essential hypertension, and the depressor effects of captopril may act through LEK and beta-EP, besides blocking formation of angiotension II.
Spec (may) Positive_regulation (act) of LEK in LEK associated with hypertension and enkephalin
3) Confidence 0.03 Published 1990 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 2169983 Disease Relevance 0.70 Pain Relevance 0.92
After 14 days of the treatment, plasma levels of beta-EP, LEK increased significantly (P < 0.001), and correlated negatively with the decrease of the mean artery pressure (r = -0.369 and r = -0.441, respectively, P < 0.01).
Positive_regulation (increased) of LEK in artery associated with enkephalin
4) Confidence 0.01 Published 1993 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Abstract Doc Link 8243225 Disease Relevance 0.17 Pain Relevance 0.69

General Comments

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