INT212983

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.08
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
blood 4
peritoneum 2
endothelial cells 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 18 99.66 Very High Very High Very High
Serotonin 12 99.46 Very High Very High Very High
bradykinin 14 99.24 Very High Very High Very High
Inflammation 122 94.40 High High
cytokine 55 92.68 High High
agonist 54 88.96 High High
Central nervous system 21 83.28 Quite High
Dopamine 1 70.08 Quite High
Neurotransmitter 11 64.80 Quite High
Hippocampus 8 62.56 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 289 100.00 Very High Very High Very High
Peritonitis 48 99.76 Very High Very High Very High
Hypoxia 16 99.76 Very High Very High Very High
Hyperalgesia 33 99.66 Very High Very High Very High
Cardiovascular Disease 22 98.96 Very High Very High Very High
Hyperinsulinism 5 98.92 Very High Very High Very High
Stress 23 98.84 Very High Very High Very High
INFLAMMATION 142 94.40 High High
Hyperglycemia 18 91.44 High High
Diabetes Mellitus 120 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two factors that modulate the development of cardiovascular diseases are HDL and estradiol [33,34], both which also can promote the stimulation of eNOS and generation of nitric oxide [35,36].
Positive_regulation (promote) of Positive_regulation (stimulation) of eNOS associated with cardiovascular disease and disorder of lipid metabolism
1) Confidence 0.51 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.54 Pain Relevance 0
At variance with the 6-day catheter peritonitis model, the upregulation of eNOS 18 h after LPS does not reflect a significant vascular proliferation in the peritoneum.
Positive_regulation (after) of Positive_regulation (upregulation) of eNOS in peritoneum associated with peritonitis
2) Confidence 0.41 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.53 Pain Relevance 0.23
Estrogen increases the expression and activity of eNOS [19], [20].
Positive_regulation (increases) of Positive_regulation (activity) of eNOS
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0 Pain Relevance 0
The present study provided the following major findings: 1) pretreatment with 7-NINA (a selective nNOS inhibitor), AG (a selective iNOS inhibitor), or L-NAME (a non-selective NOS inhibitor), but not L-NIO (a selective eNOS inhibitor), attenuated CFA-induced thermal hyperalgesia in mice; 2) CFA caused an increase of nNOS, iNOS and eNOS, as well as of TNF, IL-1?
Positive_regulation (caused) of Positive_regulation (increase) of eNOS associated with thermal hyperalgesia
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.96 Pain Relevance 0.32
Furthermore, HDL inhibit thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS (Viswambharan et al 2004).
Positive_regulation (induced) of Positive_regulation (activation) of eNOS associated with disorder of lipid metabolism
5) Confidence 0.29 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.20 Pain Relevance 0
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
Positive_regulation (required) of Positive_regulation (activation) of eNOS associated with disorder of lipid metabolism
6) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.13 Pain Relevance 0.12
The physiologic event that leads to an increased activity of eNOS is represented by the shear stress, ie, the force produced by the blood flow per surface unit of the vascular wall (Vallance et al 1989).
Positive_regulation (leads) of Positive_regulation (increased) of eNOS in blood associated with stress
7) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.62 Pain Relevance 0.04
We previously showed that hyperinsulinemia increases femoral arterial blood flow by a mechanism requiring eNOS activation (4).
Positive_regulation (requiring) of Positive_regulation (activation) of eNOS in blood associated with hyperinsulinism
8) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.26 Pain Relevance 0.15
Bringing eNOS into the picture also has repercussions for experimental design and interpretation because endothelial cells could be an active source of NO following application of many different experimental agents, bearing, as they can do, a long list of receptors (for acetylcholine, ADP, bradykinin, serotonin, histamine, etc) that are coupled to eNOS activation.


Positive_regulation (coupled) of Positive_regulation (activation) of eNOS in endothelial cells associated with serotonin and bradykinin
9) Confidence 0.14 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.21 Pain Relevance 0.37
The same agent may also stimulate angiogenesis via the induction of heme oxygenase-1 (HO-1), endothelial nitric-oxide synthase, and hypoxia-inducible factor-1a (HIF-1) [48].
Spec (may) Positive_regulation (stimulate) of Positive_regulation (induction) of endothelial nitric-oxide synthase associated with hypoxia
10) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.63 Pain Relevance 0

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