INT212985

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 43 97.08 Very High Very High Very High
Inflammation 51 88.08 High High
Central nervous system 28 79.32 Quite High
Kinase C 37 44.84 Quite Low
Eae 4 35.20 Quite Low
Hippocampus 20 21.76 Low Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 14 99.74 Very High Very High Very High
Disorder Of Lipid Metabolism 155 98.68 Very High Very High Very High
Disease 204 94.48 High High
Increased Venous Pressure Under Development 43 92.24 High High
Diabetes Mellitus 103 89.56 High High
INFLAMMATION 66 88.08 High High
Thrombosis 5 86.64 High High
Aging 16 86.44 High High
Targeted Disruption 9 82.16 Quite High
Adhesions 30 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In insulin resistance states, the activation of the PI3K pathway is inhibited, whereas the activation of the MAPK pathway is largely intact.
Negative_regulation (inhibited) of Positive_regulation (activation) of PI3K associated with insulin resistance
1) Confidence 0.19 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.13 Pain Relevance 0.21
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Negative_regulation (reduced) of Positive_regulation (activation) of PI3K
2) Confidence 0.19 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.98 Pain Relevance 0.04
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Negative_regulation (inhibitor) of Positive_regulation (concentrations) of PI3K associated with cytokine
3) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
Furthermore, HDL inhibit thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS (Viswambharan et al 2004).
Negative_regulation (inhibition) of Positive_regulation (activation) of PI3K associated with disorder of lipid metabolism
4) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.17 Pain Relevance 0

General Comments

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