INT21299

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 10.97
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp) response to stress (Hp)
Anatomy Link Frequency
blood 3
reticulocyte 2
brain 1
platelet 1
body 1
Hp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
peptic ulcer disease 7 99.92 Very High Very High Very High
Inflammation 31 99.12 Very High Very High Very High
antagonist 2 95.72 Very High Very High Very High
Arthritis 24 95.08 Very High Very High Very High
analgesia 9 93.24 High High
cINOD 3 93.12 High High
Pain 5 93.08 High High
opiate 4 92.08 High High
headache 1 92.04 High High
backache 1 85.48 High High
Disease Link Frequency Relevance Heat
Injury 23 100.00 Very High Very High Very High
Burns 22 100.00 Very High Very High Very High
Ulcers 20 100.00 Very High Very High Very High
Disease 20 99.92 Very High Very High Very High
Reticulocytosis 1 99.84 Very High Very High Very High
Hemolysis 7 99.44 Very High Very High Very High
INFLAMMATION 36 99.12 Very High Very High Very High
Body Weight 11 98.88 Very High Very High Very High
Pancreatitis 1 98.44 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 8 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a few cases with low volumes of retransfused blood the haptoglobin decrease may have been greater, so that free hemoglobin may have been present.
Negative_regulation (decrease) of haptoglobin in blood
1) Confidence 0.44 Published 1988 Journal Anaesthesist Section Abstract Doc Link 3218723 Disease Relevance 0.05 Pain Relevance 0.06
The prevalence of Hp- PUD was about 8%, mainly unrelated to any known etiologic factor.
Negative_regulation (prevalence) of Hp associated with peptic ulcer disease and ulcers
2) Confidence 0.42 Published 2000 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 10914775 Disease Relevance 2.20 Pain Relevance 0.69
The correlation between volume of retransfused autologous blood and decrease in haptoglobin level was small (r = 0.15).
Negative_regulation (decrease) of haptoglobin in blood
3) Confidence 0.32 Published 1988 Journal Anaesthesist Section Abstract Doc Link 3218723 Disease Relevance 0.11 Pain Relevance 0.07
Hemolysis was further confirmed by a decrease in haptoglobin in all patients and an increase in lactic dehydrogenase in all but the last case.
Negative_regulation (decrease) of haptoglobin associated with hemolysis
4) Confidence 0.28 Published 1996 Journal Am. J. Kidney Dis. Section Abstract Doc Link 8659503 Disease Relevance 0.38 Pain Relevance 0.09
The specific dose and time requirements for cimetidine to inhibit the HP-FSIA are probably attributable to the brain drug levels that can be achieved after peripheral administration.
Negative_regulation (inhibit) of HP-FSIA in brain
5) Confidence 0.24 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3487801 Disease Relevance 0 Pain Relevance 0.46
Cimetidine (100 mg/kg, IP) inhibited HP-FSIA when administered 30 min before testing, but was inactive when testing began sooner (15 min) or later (1-4 hr) than this time.
Negative_regulation (inhibited) of HP-FSIA
6) Confidence 0.21 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3487801 Disease Relevance 0 Pain Relevance 0.52
The acute phase proteins—haptoglobin and orosomucoid which were increased due to burn injury were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
Negative_regulation (decreased) of haptoglobin in body associated with body weight, burns and injury
7) Confidence 0.19 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2533690 Disease Relevance 1.13 Pain Relevance 0.08
The activity of WAY-169916 is related to its ability to suppress inflammatory processes globally, as demonstrated by the decrease in serum acute-phase protein levels of haptoglobin, ?
Negative_regulation (decrease) of haptoglobin associated with inflammation
8) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 1.16 Pain Relevance 0.51
The mean haptoglobin concentration at 24 hours was not significantly reduced (p = 0.178).
Neg (not) Negative_regulation (reduced) of haptoglobin
9) Confidence 0.13 Published 2010 Journal Vet Anaesth Analg Section Body Doc Link 20636569 Disease Relevance 0.11 Pain Relevance 0
A transient and variable increase in transaminase, bilirubin, white cell and D-dimer levels and a decrease in red cell, platelet, hemoglobin, fibrinogen and haptoglobin levels were observed.
Negative_regulation (decrease) of haptoglobin in platelet
10) Confidence 0.12 Published 1997 Journal Radiol Med Section Abstract Doc Link 9424644 Disease Relevance 1.68 Pain Relevance 0.17
A reticulocytosis (24%), decreased haptoglobin concentration (0.6 mg/dl) and increased lactate dehydrogenase activity (657 U/l) indicated marked haemolysis.
Negative_regulation (decreased) of haptoglobin associated with reticulocytosis
11) Confidence 0.05 Published 1990 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 2170094 Disease Relevance 0.90 Pain Relevance 0.09
After the restriction of exercise, the creatine kinase level and indirect bilirubin level decreased, and the reticulocyte count and haptoglobin level were normalized.
Negative_regulation (decreased) of haptoglobin in reticulocyte
12) Confidence 0.04 Published 1996 Journal Intern. Med. Section Abstract Doc Link 8785459 Disease Relevance 0.34 Pain Relevance 0.09
Fragmented erythrocytes were seen in peripheral blood with elevated serum lactate dehydrogenase and decreased serum haptoglobin concentrations.
Negative_regulation (decreased) of serum haptoglobin in blood
13) Confidence 0.01 Published 2002 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 12101856 Disease Relevance 1.67 Pain Relevance 0.07
Patients with TTP often have an increased reticulocyte count, elevated serum lactate dehydrogenase level, and decreased serum haptoglobin level.
Negative_regulation (decreased) of serum haptoglobin in reticulocyte associated with thrombotic thrombocytopenic purpura
14) Confidence 0.00 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17594212 Disease Relevance 1.17 Pain Relevance 0.06

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