INT212992

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.64
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
endothelial cells 2
endothelium 2
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cOX1 2 95.12 Very High Very High Very High
psoriasis 126 83.84 Quite High
Bile 5 78.00 Quite High
cytokine 9 76.16 Quite High
Inflammation 52 72.20 Quite High
Kinase C 1 66.92 Quite High
chemokine 4 55.84 Quite High
Arthritis 4 38.80 Quite Low
methotrexate 2 23.36 Low Low
alcohol 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 487 100.00 Very High Very High Very High
Congenital Anomalies 23 94.92 High High
Insulin Resistance 8 94.84 High High
Hyperlipidemia 15 94.40 High High
Obesity 13 92.88 High High
Stress 21 84.92 Quite High
Psoriasis 212 83.84 Quite High
Coagulation Disorder 2 83.16 Quite High
Dyslipidemia /

Combined Dyslipidemia

13 80.96 Quite High
Coronary Heart Disease 33 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDL also induce the phosphorylation of p38MAPK, which is implicated in the activation of CREB and subsequent HDL dependent Cox-2 induction and prostacyclin release in endothelial cells (Norata, Callegari, et al 2004).
Regulation (implicated) of Positive_regulation (induction) of HDL in endothelial cells associated with disorder of lipid metabolism
1) Confidence 0.23 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.78 Pain Relevance 0.03
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Neg (no) Regulation (change) of Positive_regulation (increase) of HDL associated with disorder of lipid metabolism
2) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.09 Pain Relevance 0.04
inhibitors affects the increase of HDL level [128]; in particular, TNF may affect endothelium dysfunction by decreasing the levels of nitric oxide synthase and cyclooxygenase 1 [127].

10.

Regulation (affects) of Positive_regulation (increase) of HDL in endothelium associated with cox1 and disorder of lipid metabolism
3) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.69 Pain Relevance 0.23
inhibitors can cause an increase of serum triglyceride levels, but they have beneficial effects on the increase of HDL level and are able to decrease blood insulin levels [141, 160–162].
Regulation (effects) of Positive_regulation (increase) of HDL in blood associated with disorder of lipid metabolism
4) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox