INT212996

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
vasculature 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 7 88.40 High High
alcohol 3 58.72 Quite High
Inflammation 25 50.00 Quite Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 137 98.68 Very High Very High Very High
Hypertension 29 89.12 High High
Adhesions 21 81.48 Quite High
Sepsis 47 75.20 Quite High
Systemic Inflammatory Response Syndrome 7 74.76 Quite High
Targeted Disruption 4 74.72 Quite High
Increased Venous Pressure Under Development 3 71.80 Quite High
Pulmonary Disease 5 70.88 Quite High
Shock 2 68.80 Quite High
Disease 6 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also suggests that androgens decrease the expression and activity of eNOS within the pulmonary vasculature.
Negative_regulation (decrease) of Positive_regulation (activity) of eNOS in vasculature
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.49 Pain Relevance 0.03
Furthermore, HDL inhibit thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS (Viswambharan et al 2004).
Negative_regulation (inhibition) of Positive_regulation (activation) of eNOS associated with disorder of lipid metabolism
2) Confidence 0.33 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.18 Pain Relevance 0
This intracellular ascorbate may protect microvascular function in two phases of action: initially by inhibiting NADPH oxidase activation and increasing eNOS activity, and subsequently by suppressing expression of NADPH oxidase, iNOS and tissue factor (Fig. 4).
Negative_regulation (inhibiting) of Positive_regulation (activation) of eNOS
3) Confidence 0.13 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.44 Pain Relevance 0.09

General Comments

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