INT213001

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
endothelium 1
Hdl1 (Mus musculus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 64.20 Quite High
cytokine 8 56.88 Quite High
chemokine 4 17.72 Low Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 274 100.00 Very High Very High Very High
Atherosclerosis 20 76.48 Quite High
Apoptosis 14 69.52 Quite High
INFLAMMATION 38 64.20 Quite High
Adhesions 36 33.56 Quite Low
Retinoblastoma 2 21.76 Low Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second mechanism has been proposed by Mineo et al (2003), which suggests that HDL via interaction with SR-B1 activate a tyrosine kinase most likely belonging to the src family kinase that phosphorylate both Akt and MAPK.
HDL Positive_regulation (activate) of kinase associated with disorder of lipid metabolism
1) Confidence 0.00 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.02 Pain Relevance 0.03
Other signaling pathways, including ERK1/2, calcium/calmodulin kinase, PKC, and p38MAPK, are activated by HDL and are involved in the effects of HDL on the endothelium.
HDL Positive_regulation (activated) of kinase in endothelium associated with disorder of lipid metabolism
2) Confidence 0.00 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.98 Pain Relevance 0.03

General Comments

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