INT213005

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.81
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Hdl1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 92.56 High High
Inflammation 31 56.84 Quite High
Kinase C 2 33.76 Quite Low
chemokine 4 6.16 Low Low
agonist 17 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 562 100.00 Very High Very High Very High
Apoptosis 17 100.00 Very High Very High Very High
INFLAMMATION 46 91.44 High High
Myocardial Infarction 25 86.64 High High
Coronary Heart Disease 33 71.36 Quite High
Coronary Artery Disease 18 66.24 Quite High
Atherosclerosis 69 62.64 Quite High
Retinoblastoma 2 57.44 Quite High
Adhesions 38 49.80 Quite Low
Necrosis 7 45.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI3K/Akt activation by HDL has also been involved in the modulation of the expression of TGF-?
HDL Positive_regulation (activation) of Akt associated with disorder of lipid metabolism
1) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.96 Pain Relevance 0.05
The activation of the PI3K/Akt pathway by HDL also maintains mitochondrial integrity by inhibiting cytochrome C release, caspase 3 and 9 activation, and apoptosis (Nofer, Levkau, et al 2001).
HDL Positive_regulation (activation) of Akt associated with apoptosis and disorder of lipid metabolism
2) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.96 Pain Relevance 0.04
HDL-associated lysosphingolipids also suppress mitochondrial pathways of apoptosis by activating the anti-apoptotic serine/threonine protein kinase, Akt (Nofer et al 2001).
HDL Positive_regulation (activating) of Akt associated with apoptosis and disorder of lipid metabolism
3) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.88 Pain Relevance 0.06

General Comments

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