INT213023

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.06
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
plasma 1
Hdl1 (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 59.00 Quite High
Bioavailability 13 56.48 Quite High
cytokine 4 29.28 Quite Low
Inflammation 13 17.92 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 165 100.00 Very High Very High Very High
Endometriosis (extended) 12 96.72 Very High Very High Very High
Cardiovascular Disease 24 95.48 Very High Very High Very High
Diabetes Mellitus 150 78.88 Quite High
Myocardial Infarction 65 65.48 Quite High
INFLAMMATION 23 58.64 Quite High
Adhesions 22 47.52 Quite Low
Retinoblastoma 1 47.08 Quite Low
Apoptosis 7 23.00 Low Low
Atherosclerosis 18 19.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of interest, studies have shown that HDL can modulate the activity of proteins present in plasma membrane microdomains, known as caveolae, including eNOS and PGI synthase (PGI-S) (Frank et al 2003).
HDL Regulation (modulate) of eNOS in plasma associated with disorder of lipid metabolism
1) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.79 Pain Relevance 0.03
Interestingly, in both mice and humans, female HDL but not male HDL has been shown to stimulate eNOS [37].
HDL Regulation (stimulate) of eNOS associated with disorder of lipid metabolism
2) Confidence 0.05 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.64 Pain Relevance 0.03
Interestingly, in both mice and humans, female HDL but not male HDL has been shown to stimulate eNOS [37].
HDL Regulation (stimulate) of eNOS associated with disorder of lipid metabolism
3) Confidence 0.05 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.63 Pain Relevance 0.03

General Comments

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