INT213026

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 7.92
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
endothelial cells 1
Hdl1 (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 95.40 Very High Very High Very High
Inflammatory response 18 92.88 High High
cytokine 17 87.04 High High
Bioavailability 7 70.96 Quite High
ischemia 15 63.72 Quite High
chemokine 6 41.52 Quite Low
Inflammatory mediators 4 27.84 Quite Low
metalloproteinase 10 8.96 Low Low
Bile 62 5.00 Very Low Very Low Very Low
agonist 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 729 100.00 Very High Very High Very High
Endometriosis (extended) 6 97.16 Very High Very High Very High
Coronary Heart Disease 66 96.16 Very High Very High Very High
Cardiovascular Disease 35 96.04 Very High Very High Very High
INFLAMMATION 90 95.40 Very High Very High Very High
Necrosis 12 94.72 High High
Coronary Artery Disease 23 91.04 High High
Apoptosis 22 90.20 High High
Injury 18 89.44 High High
Extrahepatic Cholestasis 17 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of cultured endothelial cells with HDL activates eNOS in a process that involves the binding of ApoA-I to the scavenger receptor-BI (SR-BI) (Yuhanna et al 2001; Mineo et al 2003).
HDL Positive_regulation (activates) of eNOS in endothelial cells associated with disorder of lipid metabolism
1) Confidence 0.16 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.19 Pain Relevance 0
This inability of postmenopausal HDL to stimulate eNOS [37] agrees with a more severe endothelial dysfunction in women after menopause and the increased cardiovascular disease risk [38].
HDL Positive_regulation (stimulate) of eNOS associated with endometriosis (extended), cardiovascular disease and disorder of lipid metabolism
2) Confidence 0.05 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.50 Pain Relevance 0.04
In vitro, HDL-C enhances endothelial nitric oxide synthase (eNOS) activity (Kuvin et al 2002).
HDL Positive_regulation (enhances) of endothelial nitric oxide synthase associated with disorder of lipid metabolism
3) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.94 Pain Relevance 0.17
In vitro, HDL-C enhances endothelial nitric oxide synthase (eNOS) activity (Kuvin et al 2002).
HDL Positive_regulation (enhances) of eNOS associated with disorder of lipid metabolism
4) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.94 Pain Relevance 0.17
The LPS-induced proinflammatory response is downregulated by high-density lipoproteins (HDL) that decrease the hepatic proinflammatory signals, restores eNOS activity and lowers portal pressure [91].
HDL Positive_regulation (restores) of eNOS associated with disorder of lipid metabolism
5) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 1.36 Pain Relevance 0.35

General Comments

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