INT213027

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.52
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
cell adhesion (Scarb1) plasma membrane (Scarb1) nucleus (Apoa1)
Anatomy Link Frequency
endothelial cells 2
Apoa1 (Mus musculus)
Scarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 21 75.08 Quite High
Inflammation 64 74.72 Quite High
chemokine 10 58.56 Quite High
metalloproteinase 30 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 15 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 973 99.28 Very High Very High Very High
Myocardial Infarction 34 96.48 Very High Very High Very High
Coronary Heart Disease 33 89.24 High High
Coronary Artery Disease 36 84.12 Quite High
Apoptosis 38 76.72 Quite High
INFLAMMATION 103 76.28 Quite High
Adhesions 92 67.68 Quite High
Necrosis 16 63.28 Quite High
Cancer 7 62.92 Quite High
Atherosclerotic Plaque 18 58.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This discrepancy was elegantly solved by Nofer et al (2004), which showed that the interaction of ApoA-I with SR-B1 is required for localizing the HDL particles at the membrane level where lysosphingolipids interact with specific receptors as EDG1/3 (also called S1P3) activating several intracellular signaling cascades.
ApoA-I Binding (interaction) of SR-B1 associated with disorder of lipid metabolism
1) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.08 Pain Relevance 0.03
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
ApoA-I Binding (binding) of SR-B1 associated with disorder of lipid metabolism
2) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.14 Pain Relevance 0.12
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
ApoA-I Binding (binding) of scavenger receptor-BI associated with disorder of lipid metabolism
3) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.14 Pain Relevance 0.12
Incubation of cultured endothelial cells with HDL activates eNOS in a process that involves the binding of ApoA-I to the scavenger receptor-BI (SR-BI) (Yuhanna et al 2001; Mineo et al 2003).
ApoA-I Binding (binding) of SR-BI in endothelial cells associated with disorder of lipid metabolism
4) Confidence 0.07 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.06 Pain Relevance 0
Incubation of cultured endothelial cells with HDL activates eNOS in a process that involves the binding of ApoA-I to the scavenger receptor-BI (SR-BI) (Yuhanna et al 2001; Mineo et al 2003).
ApoA-I Binding (binding) of scavenger receptor-BI in endothelial cells associated with disorder of lipid metabolism
5) Confidence 0.07 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.06 Pain Relevance 0
The mechanism of HDL-C mediated eNOS activation remains unknown, however may involve an interaction between endothelial SR-B1 and Apo AI (Yuhanna et al 2001).
Apo AI Binding (interaction) of SR-B1 associated with disorder of lipid metabolism
6) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 2.02 Pain Relevance 0.16

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