INT213029

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.38
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
cell adhesion (Scarb1) plasma membrane (Scarb1) nucleus (Apoa1)
Apoa1 (Mus musculus)
Scarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 66.96 Quite High
chemokine 6 58.56 Quite High
cytokine 12 57.52 Quite High
metalloproteinase 18 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 411 99.80 Very High Very High Very High
INFLAMMATION 57 76.28 Quite High
Adhesions 54 18.56 Low Low
Apoptosis 21 6.72 Low Low
Atherosclerosis 30 5.00 Very Low Very Low Very Low
Coronary Artery Disease 18 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This discrepancy was elegantly solved by Nofer et al (2004), which showed that the interaction of ApoA-I with SR-B1 is required for localizing the HDL particles at the membrane level where lysosphingolipids interact with specific receptors as EDG1/3 (also called S1P3) activating several intracellular signaling cascades.
Positive_regulation (required) of ApoA-I Binding (interaction) of SR-B1 associated with disorder of lipid metabolism
1) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.08 Pain Relevance 0.03
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
Positive_regulation (required) of ApoA-I Binding (binding) of SR-B1 associated with disorder of lipid metabolism
2) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.15 Pain Relevance 0.12
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
Positive_regulation (required) of ApoA-I Binding (binding) of scavenger receptor-BI associated with disorder of lipid metabolism
3) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.15 Pain Relevance 0.12

General Comments

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