INT213042

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2005
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.17
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Apoa1, Nos3) mitochondrion (Nos3) Golgi apparatus (Nos3)
enzyme binding (Apoa1) cytoplasm (Nos3) lipid binding (Apoa1)
Apoa1 (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 62.08 Quite High
chemokine 4 53.68 Quite High
cytokine 8 52.64 Quite High
metalloproteinase 12 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 274 98.98 Very High Very High Very High
INFLAMMATION 38 71.40 Quite High
Necrosis 6 56.96 Quite High
Cancer 2 53.56 Quite High
Apoptosis 14 52.88 Quite High
Death 10 42.92 Quite Low
Atherosclerotic Plaque 6 26.00 Quite Low
Adhesions 36 13.68 Low Low
Atherosclerosis 20 5.00 Very Low Very Low Very Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoA-I binding to the scavenger receptor-BI (SR-B1) is required for HDL activation of eNOS (Yuhanna et al 2001); however, eNOS is not activated by lipid-free ApoA-I.
ApoA-I Neg (not) Positive_regulation (activated) of eNOS associated with disorder of lipid metabolism
1) Confidence 0.10 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.16 Pain Relevance 0.11
However, eNOS is not activated by lipidfree ApoA-I.
ApoA-I Neg (not) Positive_regulation (activated) of eNOS
2) Confidence 0.10 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.01 Pain Relevance 0

General Comments

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