INT213071

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 6.58
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, CRP) extracellular region (IL6, CRP) aging (IL6)
Anatomy Link Frequency
macrophages 2
liver 2
IL6 (Homo sapiens)
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 62 100.00 Very High Very High Very High
Inflammation 39 97.92 Very High Very High Very High
cva 15 97.64 Very High Very High Very High
Inflammatory response 8 94.48 High High
Angina 20 85.52 High High
Inflammatory marker 7 68.00 Quite High
ischemia 11 65.24 Quite High
depression 2 7.04 Low Low
palliative 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 119 100.00 Very High Very High Very High
Atherosclerotic Plaque 7 100.00 Very High Very High Very High
INFLAMMATION 56 97.92 Very High Very High Very High
Angina 11 97.64 Very High Very High Very High
Chronic Renal Failure 1 95.76 Very High Very High Very High
Infection 2 94.68 High High
Injury 15 94.24 High High
Atherosclerosis 13 92.80 High High
Acute Coronary Syndrome 10 91.92 High High
Appetite Loss 7 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 gene transcripts are expressed in human atheromatous lesions (Rus et al 1996), and IL-6 is the main hepatic stimulus for C-reactive protein (CRP) production (Kulmatycki et al 2001).
IL-6 Positive_regulation (stimulus) of Gene_expression (production) of CRP
1) Confidence 0.52 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993951 Disease Relevance 1.58 Pain Relevance 0.43
IL-6 gene transcripts are expressed in human atheromatous lesions (Rus et al 1996), and IL-6 is the main hepatic stimulus for C-reactive protein (CRP) production (Kulmatycki et al 2001).
IL-6 Positive_regulation (stimulus) of Gene_expression (production) of C-reactive protein
2) Confidence 0.52 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993951 Disease Relevance 1.58 Pain Relevance 0.43
IL-6, a proinflammatory cytokine produced by macrophages in atherosclerotic plaque, induces hepatic synthesis of all the acute phase proteins, including CRP [54,62].
IL-6 Positive_regulation (induces) of Gene_expression (synthesis) of CRP in macrophages associated with atherosclerotic plaque and cytokine
3) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 2.16 Pain Relevance 0.57
Interleukin-6, produced by the tumor or surrounding cells, stimulates liver production of acute-phase reaction proteins (such as C-reactive protein (CRP) and fibrinogen) in both the fasted and fed states.
Interleukin-6 Positive_regulation (stimulates) of Gene_expression (production) of C-reactive protein in liver associated with cancer
4) Confidence 0.18 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.26 Pain Relevance 0.24

General Comments

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