INT213081

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.14
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Egfl7) extracellular space (Egfl7) extracellular region (Egfl7)
Anatomy Link Frequency
blood 1
Egfl7 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 97.84 Very High Very High Very High
Tendonitis 2 70.72 Quite High
depression 1 52.80 Quite High
imagery 12 19.60 Low Low
Inflammation 19 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 97 99.84 Very High Very High Very High
Hypertension 12 99.44 Very High Very High Very High
Stroke 22 99.24 Very High Very High Very High
Adhesions 2 98.70 Very High Very High Very High
Diabetes Mellitus 49 98.40 Very High Very High Very High
Death 28 98.40 Very High Very High Very High
Myalgia 9 98.10 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

14 97.92 Very High Very High Very High
Metabolic Syndrome 24 96.16 Very High Very High Very High
Apoptosis 51 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that a farnesylated protein can partially inhibit Statin/TGF-?
Negative_regulation (inhibit) of Statin
1) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.77 Pain Relevance 0
It is possible that use of other agents such as plant sterols and ezetimibe could allow for a reduction in statin dose and improved compliance with long-term therapy.


Negative_regulation (reduction) of statin
2) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 1.10 Pain Relevance 0.03
In patients with mixed dyslipidemia, use of fenofibrate is preferable to gemfibrozil, since fenofibrate is not associated with significant inhibition of statin metabolism [54].
Negative_regulation (inhibition) of statin
3) Confidence 0.01 Published 2010 Journal Current Gerontology and Geriatrics Research Section Body Doc Link PMC2902014 Disease Relevance 0.31 Pain Relevance 0
There was a reduction in serum triglycerides after 4 weeks' statin intervention (?
Negative_regulation (reduction) of statin
4) Confidence 0.01 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993963 Disease Relevance 0.51 Pain Relevance 0
Reductions in LDL cholesterol according to statin and dose and reduction in IHD events and stroke for a specified reduction in LDL cholesterol were calculated.
Negative_regulation (reduction) of statin associated with coronary artery disease and stroke
5) Confidence 0.00 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672446 Disease Relevance 0.83 Pain Relevance 0
In the case of myalgia it is recommended that patients undergo: (1) creatine kinase measurements and monitoring; (2) statin dosage reduction, discontinuation, and rechallenge; and (3) alternate-day therapy.11
Negative_regulation (reduction) of statin associated with myalgia
6) Confidence 0.00 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672446 Disease Relevance 0.96 Pain Relevance 0.07
It also reduces hepatic release of lipoprotein into the blood circulation.23) Despite of lipid lowering effects, statins have other pleiotrophic effects including inhibition of migration and proliferation of arterial myocytes, inhibition of macrophage growth, inhibition of metalloproteinase secretion, and Inhibition of cell adhesion.24) Currently, there are no studies which have demonstrated the statin effect (decrease) on the thickness of adipose tissues.
Negative_regulation (decrease) of statin in blood associated with metalloproteinase and adhesions
7) Confidence 0.00 Published 2010 Journal Journal of Cardiovascular Ultrasound Section Body Doc Link PMC3021889 Disease Relevance 0.56 Pain Relevance 0.05

General Comments

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