INT2131

Context Info Confidence 0.47 First Reported 1978 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.01 Pain Relevance 0.88

extracellular region (SCT) cellular_component (SCT)

Anatomy Link Frequency duodenum 5 plasma 2 acinar cells 1 SCT (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 6 100.00 alcohol 78 98.00 Bile 1 97.56 Nicotine 49 90.92 vagus nerve 5 86.64 Chronic pancreatitis 11 81.28 Inflammation 3 62.44 Pain 19 35.36 antagonist 11 5.56 tolerance 9 5.00

Disease Link Frequency Relevance Heat Exocrine Pancreatic Insufficiency 1 96.80 Pancreatic Cancer 140 95.96 Infection 37 95.08 Pancreatitis 87 82.32 Nicotine Addiction 94 70.08 Body Weight 1 64.16 INFLAMMATION 7 62.44 Ulcers 12 50.00 Poisoning 14 47.56 Pain 19 35.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Otherwise a weak stimulation occurs with release of secretin.

Positive_regulation (occurs) of Localization (release) of secretin

1) Confidence 0.47 Published 1978 Journal Leber Magen Darm Section Abstract Doc Link 359968 Disease Relevance 0.08 Pain Relevance 0.29

The concentrations of secretin and CCK in plasma and the pancreatic enzyme and volume secretions were unaffected by the addition of trypsin, but the initial bile acid output and the bicarbonate secretion in the period after gallbladder emptying were reduced during perfusion with trypsin.

Positive_regulation (concentrations) of Localization (secretions) of secretin in plasma associated with bile and cholecystokinin

2) Confidence 0.31 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.29

Gastrin affects pancreatic secretion by two mechanisms: gastric acid secretion, resulting in secretin secretion when a low pH reaches the duodenum and a direct effect of gastrin on acinar cells to produce an enzyme-rich secretion.

Positive_regulation (resulting) of in duodenum Localization (secretion) of secretin in acinar cells

3) Confidence 0.20 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.13 Pain Relevance 0.11

Antral colonization by H. pylori has been associated with increased gastric acid output which will lead to increased secretin release from the duodenum.

Positive_regulation (lead) of Localization (release) of secretin in duodenum

4) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2613155 Disease Relevance 0.84 Pain Relevance 0.04

Antral colonization by H. pylori has been associated with increased gastric acid output which will lead to increased secretin release from the duodenum.

Positive_regulation (increased) of Localization (release) of secretin in duodenum

5) Confidence 0.13 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2613155 Disease Relevance 0.79 Pain Relevance 0.04

He suggested that alkaloids such as pilocarpine, atropine, and strychnine, likewise acted in this manner, as might other internally secreted substances (i.e. hormones), such as secretin, thyroidin, and “the various stimulating chemical bodies formed by the generative organs”.74 More than this, Langley proposed a general rule:

Positive_regulation (formed) of Localization (secreted) of secretin

6) Confidence 0.04 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0 Pain Relevance 0.10

General Comments

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