INT213118

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.86
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) transport (Apoa1) extracellular space (Apoa1)
extracellular region (Apoa1) nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
liver 2
Apoa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 97.84 Very High Very High Very High
Multiple sclerosis 48 97.16 Very High Very High Very High
Central nervous system 7 90.64 High High
rheumatoid arthritis 17 76.40 Quite High
pruritus 3 75.72 Quite High
Inflammatory response 1 72.32 Quite High
nud 1 68.12 Quite High
Inflammation 9 59.60 Quite High
Demyelination 2 56.00 Quite High
cytokine 8 33.40 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 100.00 Very High Very High Very High
Injury 2 98.96 Very High Very High Very High
Demyelinating Disease 59 97.16 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

12 96.56 Very High Very High Very High
Metabolic Syndrome 6 95.88 Very High Very High Very High
Coronary Artery Disease 2 94.16 High High
Diabetes Mellitus 10 92.16 High High
Hypertension 4 91.04 High High
Autoimmune Disease 8 82.88 Quite High
Muscle Disease 1 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a large number of serum apoA-I synthesized by liver will be albe to meet the remyelination during acute phase of MS.
Negative_regulation (number) of Gene_expression (synthesized) of apoA-I in liver associated with multiple sclerosis
1) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.11 Pain Relevance 0.49
Lovastatin and niacin in low doses used in the present study resulted in a significant decline in LDL cholesterol, triglycerides, and lp(a) along with an increase in HDL cholesterol and apoA1/apoB ratio.
Negative_regulation (decline) of Gene_expression (ratio) of apoA1 associated with disorder of lipid metabolism
2) Confidence 0.07 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993969 Disease Relevance 1.38 Pain Relevance 0.11

General Comments

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