INT213135

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.06 Pain Relevance 0

cell adhesion (Scarb1) plasma membrane (Scarb1) cytoplasm (Scarb1)

Anatomy Link Frequency liver 2 Scarb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 12 44.44 cytokine 2 8.24 alcohol 14 5.00 Bioavailability 4 5.00 addiction 4 5.00 Calcium channel 4 5.00 Angina 2 5.00 Inflammatory response 2 5.00 Bile 2 5.00 potassium channel 2 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 30 98.24 Dyslipidemia / Combined Dyslipidemia 12 93.68 Atherosclerosis 72 76.28 Stress 30 66.24 Hypertension 76 65.60 Coronary Artery Disease 6 64.24 INFLAMMATION 16 44.44 Cardiovascular Disease 30 22.04 Hypercholesterolemia 2 11.16 Adhesions 12 5.76

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been suggested that AGEs interfere with reverse cholesterol transport by suppressing scavenger receptor B1 (SR-B1)-mediated uptake of cholesterol ester from HDL by liver and SR-B1-mediated cholesterol efflux from peripheral cells (Horiuchi et al 2003).

Negative_regulation (suppressing) of scavenger receptor B1 in liver associated with disorder of lipid metabolism

1) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.93 Pain Relevance 0

It has been suggested that AGEs interfere with reverse cholesterol transport by suppressing scavenger receptor B1 (SR-B1)-mediated uptake of cholesterol ester from HDL by liver and SR-B1-mediated cholesterol efflux from peripheral cells (Horiuchi et al 2003).

Negative_regulation (suppressing) of SR-B1 in liver associated with disorder of lipid metabolism

2) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.94 Pain Relevance 0

General Comments

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