INT213172

Context Info Confidence 0.41 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.04

Anatomy Mention Frequency tubule 2

Pain Term Frequency Confidence Heat medulla 3 73.44 beta blocker 3 5.00 cytokine 1 5.00 Clonidine 1 5.00 Intracerebroventricular 1 5.00 Calcium channel 1 5.00

Disease Term Frequency Confidence Heat Hypotension 2 91.44 Natriuresis 9 89.36 Obesity 70 58.32 Cv Unclassified Under Development 1 54.64 Hypertension 25 54.40 Insulin Resistance 1 5.00 Heart Rate Under Development 1 5.00 Weight Loss 5 5.00 [[ / [[]]]] 1 5.00 Chronic Renal Failure 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been demonstrated that endogenously-produced NO inhibits renal sodium reabsorption in most of the tubule segments apparently through a decrease in the activity of both apical transporters and basolateral Na/K-ATPases (Ortiz and Garvin 2002).

Negative_regulation (decrease) of Gene_expression (produced) of Ortiz in tubule

1) Confidence 0.41 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

This test has worked.