INT213240

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 47.20 Quite Low
beta blocker 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 87.72 High High
Disease 5 86.56 High High
Myocardial Infarction 36 82.24 Quite High
Diabetes Mellitus 17 80.36 Quite High
Renal Disease 12 79.96 Quite High
Heart Rate Under Development 12 69.92 Quite High
Death 9 68.52 Quite High
Hypertension 40 50.00 Quite Low
Polyuria 2 48.44 Quite Low
Cough 3 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the theoretical benefits of combined ACEI-based and ARB-based therapy may enhance BP control and improve clinical outcomes in some subpopulations of patients, in 2006, Weber and Giles22 already observed that, for the most patients, these RAAS-based therapies do not reduce the risk for major cardiovascular events to the expected extent based on the vital role of the RAAS in the pathophysiology of hypertension and cardiorenal disease.
Positive_regulation (enhance) of Regulation (control) of BP associated with pressure and volume under development and disease
1) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.84 Pain Relevance 0
In conclusion, data from clinical trials with zofenopril–HCTZ indicate that this combination provides optimal BP control in a larger proportion of patients compared with monotherapy, whilst maintaining the tolerability profile observed with each individual component and thereby enhancing patient compliance.
Positive_regulation (provides) of Regulation (control) of BP
2) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.21 Pain Relevance 0

General Comments

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