INT213263

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS, EDN1) extracellular region (INS, EDN1) cell-cell signaling (INS, EDN1)
small molecule metabolic process (INS) carbohydrate metabolic process (INS) cytoplasm (EDN1)
Anatomy Link Frequency
skeletal muscle 1
INS (Homo sapiens)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 80.08 Quite High
Angina 1 7.24 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 6 83.84 Quite High
INFLAMMATION 3 80.08 Quite High
Polycystic Ovary Syndrome 83 76.44 Quite High
Coronary Heart Disease 7 62.72 Quite High
Carotid Artery Diseases 1 45.92 Quite Low
Reprotox - General 1 1 43.76 Quite Low
Diabetes Mellitus 18 35.60 Quite Low
Hypertension 12 34.80 Quite Low
Obesity 43 31.28 Quite Low
Disorder Of Lipid Metabolism 5 11.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been found that in the skeletal muscle circulation insulin stimulates both endothelin-1 and NO activity, and an imbalance between the release of these two substances may be involved in the pathophysiology of endothelial dysfunction.
insulin Positive_regulation (stimulates) of endothelin-1 in skeletal muscle
1) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 0.54 Pain Relevance 0.04

General Comments

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