INT213272

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 9.13
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
muscle 5
liver 1
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 99.70 Very High Very High Very High
tolerance 23 83.96 Quite High
Inflammation 20 83.60 Quite High
cytokine 5 25.16 Quite Low
Inflammatory stimuli 1 23.68 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 90 99.70 Very High Very High Very High
Polycystic Ovary Syndrome 166 99.00 Very High Very High Very High
Targeted Disruption 8 97.60 Very High Very High Very High
Obesity 192 95.40 Very High Very High Very High
Toxicity 9 95.12 Very High Very High Very High
Diabetes Mellitus 131 94.44 High High
Weight Gain 3 93.88 High High
Death 7 90.72 High High
Disease 48 85.28 High High
Cognitive Disorder 1 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A unique defect in serine phosphorylation of the insulin receptor that resulted in decreased activation of the receptor has been identified in about 50% of women with PCOS (Zhang et al 1995).
Negative_regulation (defect) of Phosphorylation (phosphorylation) of insulin associated with polycystic ovary syndrome
1) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.56 Pain Relevance 0.08
Studies suggest that insulin induced receptor autophosphorylation is markedly diminished in approximately 50% of PCOS women.
Negative_regulation (diminished) of Phosphorylation (autophosphorylation) of insulin associated with polycystic ovary syndrome
2) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.43 Pain Relevance 0
This results in a decrease in autophosphorylation of the insulin receptor.
Negative_regulation (decrease) of Phosphorylation (autophosphorylation) of insulin
3) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.11 Pain Relevance 0
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of insulin in muscle associated with insulin resistance
4) Confidence 0.21 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.77 Pain Relevance 0
Mechanisms involved in FFA-induced insulin resistance include accumulation (in muscle and liver) of lipids and lipid intermediates, including diacylglycerol; activation of several protein kinase C isoforms; and reduction in tyrosine phosphorylation of insulin receptor substrate-1/2 (6–8).
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of insulin in muscle associated with kinase c and insulin resistance
5) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2518495 Disease Relevance 1.59 Pain Relevance 0.16
insulin-signaling pathway that inhibits S112 phosphorylation of PPAR?
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of insulin
6) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 1.00 Pain Relevance 0.03
Mechanisms involved in FFA-induced insulin resistance include accumulation (in muscle and liver) of lipids and lipid intermediates, including diacylglycerol; activation of several protein kinase C isoforms; and reduction in tyrosine phosphorylation of insulin receptor substrate-1/2 (6–8).
Negative_regulation (reduction) of in liver Phosphorylation (phosphorylation) of insulin in muscle associated with kinase c and insulin resistance
7) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2518495 Disease Relevance 1.59 Pain Relevance 0.16

General Comments

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