INT213275

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.24
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
adrenal glands 3
blood 2
ovaries 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 87.52 High High
tolerance 4 85.28 High High
corticosteroid 2 71.76 Quite High
Inflammation 34 69.32 Quite High
withdrawal 1 6.48 Low Low
cva 26 5.00 Very Low Very Low Very Low
medulla 25 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 50 94.32 High High
Diabetes Mellitus 21 94.08 High High
Hirsutism 32 92.08 High High
Polycystic Ovary Syndrome 135 91.36 High High
Obesity 55 89.76 High High
Reprotox - General 2 4 89.76 High High
Weight Loss 8 89.36 High High
Acne 129 88.72 High High
Impaired Glucose Tolerance 4 86.64 High High
Cardiovascular Disease 9 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Still, some of them increase the hepatogen production of SHBG–reducing, free testosterone levels.
Positive_regulation (increase) of Gene_expression (production) of SHBG
1) Confidence 0.46 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.07 Pain Relevance 0.04
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Positive_regulation (increase) of Gene_expression (levels) of SHBG
2) Confidence 0.41 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0.04
Loss of significant weight has been reported to result in spontaneous resumption of ovulation (Crosignani et al 2003), improvement in fertility (Norman et al 2004), increased SHBG, and reduced basal level of insulin (Huber-Buchholz et al 1999; Tolino et al 2005).
Positive_regulation (increased) of Gene_expression (level) of SHBG
3) Confidence 0.41 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.59 Pain Relevance 0.04
Additionally, combined OCs directly inhibit androgenesis by the ovaries and adrenal glands.14 The estrogenic component of these agents increase hepatic production of sex hormone binding globulin (SHBG) which binds to testosterone, thereby reducing levels of bioavailable testosterone.
Positive_regulation (increase) of Gene_expression (production) of SHBG in adrenal glands
4) Confidence 0.28 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971705 Disease Relevance 0.48 Pain Relevance 0.03
Age and sex significantly impacted blood pressure: the mean sBP was higher in younger than in older subjects (p = 0.006) and also higher in male than in female subjects (p < 0.001); the SD of the sBP was larger in older than in younger subjects (p = 0.048).
Positive_regulation (larger) of Gene_expression (higher) of sBP in blood
5) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0
Additionally, combined OCs directly inhibit androgenesis by the ovaries and adrenal glands.14 The estrogenic component of these agents increase hepatic production of sex hormone binding globulin (SHBG) which binds to testosterone, thereby reducing levels of bioavailable testosterone.
Positive_regulation (increase) of in ovaries Gene_expression (production) of SHBG in adrenal glands
6) Confidence 0.10 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971705 Disease Relevance 0.48 Pain Relevance 0.03

General Comments

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