INT213277

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 17.70
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plaque 6
fat 4
coronary artery 2
myocardium 2
skeletal muscle 2
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 146 99.54 Very High Very High Very High
Angina 21 92.52 High High
headache 3 84.08 Quite High
withdrawal 1 83.72 Quite High
Inflammatory marker 4 83.36 Quite High
cytokine 39 80.20 Quite High
tolerance 28 73.20 Quite High
Inflammatory response 12 47.16 Quite Low
Inflammatory mediators 18 44.00 Quite Low
GABAergic 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 232 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 159 100.00 Very High Very High Very High
Weight Loss 239 99.84 Very High Very High Very High
Atherosclerotic Plaque 49 99.66 Very High Very High Very High
Obesity 515 99.64 Very High Very High Very High
Pulmonary Disease 97 99.58 Very High Very High Very High
INFLAMMATION 188 99.54 Very High Very High Very High
Adhesions 28 99.52 Very High Very High Very High
Diabetes Mellitus 522 99.00 Very High Very High Very High
Heart Rate Under Development 40 98.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume, adiponectin levels were predictive of coronary atherosclerotic plaque burden, i.e. an increase in adiponectin levels by 27.8 µg/ml is associated with the reduction of one atherosclerotic plaque (estimate: ?
Positive_regulation (increase) of Gene_expression (levels) of adiponectin in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerotic plaque, obesity, hypertension and disorder of lipid metabolism
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.54 Pain Relevance 0
Furthermore, an increase in adiponectin levels by 13.2 µg/ml is associated with the reduction of one non-calcified plaque (estimate: ?
Positive_regulation (increase) of Gene_expression (levels) of adiponectin in plaque
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.51 Pain Relevance 0
Our data suggest that the number of mixed and non-calcified plaques decrease by 1 for each 11.5 µg/ml and 13.2 µg/ml increase in serum adiponectin levels, respectively.
Positive_regulation (increase) of Gene_expression (levels) of adiponectin in plaques
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.54 Pain Relevance 0.08
The obese groups had lower levels of total and high molecular weight (HMW) adiponectin (P = 0.027 and P < 0.001, respectively), and as expected, higher concentrations of leptin (P < 0.001).
Positive_regulation (concentrations) of Gene_expression (levels) of adiponectin associated with obesity
4) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 0.43 Pain Relevance 0
Corrected for placebo values, the rate of increase in serum adiponectin levels in IGOB131 group followed an exponential curve (Figure 4).


Positive_regulation (increase) of Gene_expression (levels) of adiponectin
5) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.52 Pain Relevance 0.08
A study in rats showed that DNJ and mulberry leaf extract increased the serum adiponectin level and stimulated AMP-activated protein kinase to activate the ?
Positive_regulation (increased) of Gene_expression (level) of adiponectin in leaf
6) Confidence 0.31 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.39 Pain Relevance 0
This strongly indicates that patients with insulin resistance or elevated adiponectin levels may have certain subclinical features, such as chronic low-grade inflammation, that can increase the risk related to cardiac surgery.
Positive_regulation (elevated) of Gene_expression (resistance) of adiponectin associated with inflammation and insulin resistance
7) Confidence 0.30 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 1.04 Pain Relevance 0.18
Levels of adiponectin are increased by weight reduction and by thiazoledinediones (Yu et al 2002).
Positive_regulation (increased) of Gene_expression (Levels) of adiponectin associated with weight loss
8) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.94 Pain Relevance 0.09
Moreover, the "AtheroGene study", including 1890 patients with coronary artery disease, found a positive correlation between adiponectin levels and the risk of a new cardiovascular event (HR 1.17 for each increase in adiponectin quartile) [20].
Positive_regulation (increase) of Gene_expression (quartile) of adiponectin in coronary artery associated with coronary artery disease
9) Confidence 0.26 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.96 Pain Relevance 0.03
Acute exacerbations of COPD are associated with increases in serum leptin levels and the leptin/adiponectin ratio, and these elevations were related to serum IL-6 and TNF-?
Positive_regulation (increases) of Gene_expression (ratio) of adiponectin associated with pulmonary disease
10) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.78 Pain Relevance 0.22
The mechanism may be blockade of CB1 receptors by rimonabant leading to increased production of adiponectin, which would result in reduced abdominal fat deposition, and hence lower cardiovascular risk (Després et al. 2005a; Van Gaal et al. 2005).
Positive_regulation (leading) of Gene_expression (production) of adiponectin in fat
11) Confidence 0.18 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.64 Pain Relevance 0
The weight loss-independent effect of rimonabant has been postulated as being due to increased mRNA expression of adiponectin by peripheral adipose tissues, leading to beneficial improvements in fatty-acid oxidation (Van Gaal et al. 2005).
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in adipose tissues associated with weight loss
12) Confidence 0.13 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 0.98 Pain Relevance 0
Furthermore, other cardiovascular risk factors improved during rimonabant treatment, including increased HDL-C and adiponectin, and reduced TG, LDL:HDL and total:HDL-C ratios, and leptin and C-reactive protein levels.
Positive_regulation (increased) of Gene_expression (levels) of adiponectin associated with disorder of lipid metabolism
13) Confidence 0.13 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.60 Pain Relevance 0
First, as described above; it has an important anti-inflammatory effects that involve decreasing circulating adipokines levels (eg, TNF, PAI-1, leptin), which are reflected by reduced high-sensitivity C-reactive protein levels; increasing adiponectin levels; decreasing vascular expression of adhesion molecules (Wakino et al 2002).
Positive_regulation (increasing) of Gene_expression (levels) of adiponectin associated with inflammation and adhesions
14) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.61 Pain Relevance 0.08
The mechanism may be blockade of CB1 receptors by rimonabant leading to increased production of adiponectin, which would result in reduced abdominal fat deposition, and hence lower cardiovascular risk (Després et al. 2005a; Van Gaal et al. 2005).
Positive_regulation (increased) of Gene_expression (production) of adiponectin in fat
15) Confidence 0.12 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.64 Pain Relevance 0
It seems that low adiponectin production contributes to insulin resistance and there is evidence that adiponectin decreases circulating FFA levels by increasing fatty acid oxidation by skeletal muscle [101].
Positive_regulation (contributes) of Gene_expression (production) of adiponectin in skeletal muscle associated with insulin resistance
16) Confidence 0.07 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.84 Pain Relevance 0.15
It was recently suggested to have health benefits by modulating the state of coronary arteries and myocardium through paracrine and direct secretion of pro and anti-inflammatory adipokines, including increased adiponectin production ([154] and references therein).
Positive_regulation (increased) of Gene_expression (production) of adiponectin in myocardium associated with inflammation
17) Confidence 0.06 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.75 Pain Relevance 0.22

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