INT213286

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.85
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 38 93.84 High High
aspirin 1 93.76 High High
Inflammation 15 93.40 High High
alcohol 2 83.88 Quite High
Pain 13 72.72 Quite High
Onset of action 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 304 99.70 Very High Very High Very High
Hyperglycemia 29 99.10 Very High Very High Very High
Disease 35 98.76 Very High Very High Very High
Mental Disorders 1 95.20 Very High Very High Very High
Insulin Resistance 68 94.76 High High
Impaired Glucose Tolerance 50 93.84 High High
INFLAMMATION 18 93.40 High High
Alcohol Addiction 1 84.12 Quite High
Iron Overload 1 82.64 Quite High
Aging 22 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin secretion decreases with increased hyperglycemia (g1ucotoxicity), and diabetic subjects have increased levels of proinsulin, which is recognized by some (but not all) insulin assays.21 Insulin is reported to have considerable cross-reactivity with proinsulin.19,20,22 While the euglycemic clamp test is widely regarded as the 'gold standard' for sensitivity measurement, it remains a laboratory procedure, because it requires sophisticated equipment, highly trained personnel, and is a lengthy procedure.
Positive_regulation (increased) of proinsulin Binding (recognized) of associated with hyperglycemia and diabetes mellitus
1) Confidence 0.50 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 0.89 Pain Relevance 0.08
In recognizing the barriers to achieving current glycemic targets, the Global Partnership for Effective Diabetes Management now recommends that combination therapy or insulin should be initiated immediately for all patients with HbA1c ?
Positive_regulation (immediately) of insulin Binding (initiated) of associated with diabetes mellitus
2) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.88 Pain Relevance 0.06
examples of the partially closed-loop controls are the automated insulin dosage
Positive_regulation (automated) of insulin Binding (dosage) of
3) Confidence 0.50 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.10 Pain Relevance 0.07
When to initiate insulin; and

?

Positive_regulation (When) of insulin Binding (initiate) of
4) Confidence 0.50 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 1.23 Pain Relevance 0
Pharmacological treatment for these patients was insulin, 31 patients; metformin, 37 patients; sulfonylureas, 16 patients; statins, 34 patients; fibrates, 9 patients; blood pressure–lowering agents, 38 patients; aspirin, 42 patients; and allopurinol, 3 patients.
Positive_regulation (was) of insulin Binding (treatment) of in blood associated with aspirin
5) Confidence 0.28 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.97 Pain Relevance 0.14
The age-associated reduction in glucose uptake is not due to impaired insulin binding, but instead to a defect in the postreceptor intracellular insulin signaling pathway [53, 55–57].
Neg (not) Positive_regulation (due) of insulin Binding (binding) of
6) Confidence 0.24 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.77 Pain Relevance 0.11

General Comments

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