INT213305

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.81
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Eras) plasma membrane (Eras) GTPase activity (Eras)
cellular_component (Eras) biological_process (Eras)
Anatomy Link Frequency
colon 2
liver 1
smooth muscle cells 1
Eras (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 77 100.00 Very High Very High Very High
headache 7 88.64 High High
Pain 10 70.32 Quite High
Bioavailability 3 48.40 Quite Low
withdrawal 3 25.92 Quite Low
Bile 9 5.00 Very Low Very Low Very Low
cocaine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 294 100.00 Very High Very High Very High
Congenital Anomalies 21 99.78 Very High Very High Very High
Colon Cancer 24 99.24 Very High Very High Very High
Disease 84 96.24 Very High Very High Very High
Vomiting 7 89.52 High High
Increased Venous Pressure Under Development 21 89.04 High High
Headache 7 88.64 High High
Common Cold 3 88.24 High High
Pressure And Volume Under Development 10 86.12 High High
Dyspnea 23 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Tapas-study was conceived to determine which of the three treatment programs: open conventional surgery, open 'ERAS' surgery or laparoscopic 'ERAS' surgery for patients with colon carcinomas is most cost minimizing?


ERAS Binding (surgery) of in colon associated with colon cancer
1) Confidence 0.16 Published 2010 Journal BMC Surg Section Abstract Doc Link PMC2901198 Disease Relevance 0.26 Pain Relevance 0
The Tapas-study was conceived to determine which of the three treatment programs: open conventional surgery, open 'ERAS' surgery or laparoscopic 'ERAS' surgery for patients with colon carcinomas is most cost minimizing?


ERAS Binding (open) of in colon associated with colon cancer
2) Confidence 0.16 Published 2010 Journal BMC Surg Section Abstract Doc Link PMC2901198 Disease Relevance 0.26 Pain Relevance 0
Overall, compared to placebo, ERAs were not associated with a significant change in mortality (RR 0.58, CI 0.21 to 1.60).
ERAs Binding (associated) of associated with antagonist
3) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2835653 Disease Relevance 0.49 Pain Relevance 0.27
Endothelin receptor antagonists (ERAs) act on the endothelin pathway by blocking binding of endothelin-1 to its receptors (endothelin type-A [ETA] and/or type-B [ETB]) on the surface of endothelial and smooth muscle cells.
ERAs Binding (binding) of in smooth muscle cells associated with antagonist
4) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1994051 Disease Relevance 0.86 Pain Relevance 0.10
Current sulfonamide-class ERAs developed for the treatment of PAH are associated with potentially significant drug-drug interactions.
ERAs Binding (associated) of associated with pulmonary hypertension and antagonist
5) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994051 Disease Relevance 0.17 Pain Relevance 0.05
Liver abnormalities have been associated with the sulfonamide-class ERAs and to date necessitate monthly liver function testing (LFT).
ERAs Binding (associated) of in liver associated with congenital anomalies and antagonist
6) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994051 Disease Relevance 0.77 Pain Relevance 0.18

General Comments

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