INT213379

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.03
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
nucleus 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 85 99.76 Very High Very High Very High
beta blocker 4 98.16 Very High Very High Very High
antagonist 23 97.12 Very High Very High Very High
cytokine 1 92.16 High High
withdrawal 28 70.48 Quite High
palliative 6 66.40 Quite High
MU agonist 2 30.08 Quite Low
Potency 10 5.00 Very Low Very Low Very Low
addiction 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 268 94.04 High High
Prostate Cancer 136 85.56 High High
Apoptosis 36 47.68 Quite Low
Targeted Disruption 12 42.72 Quite Low
Opiate Addiction 2 12.28 Low Low
Asthma 38 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Metastasis 23 5.00 Very Low Very Low Very Low
Pulmonary Disease 22 5.00 Very Low Very Low Very Low
Airway Obstruction 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients, AR overexpression can result from gene amplification, increased transcription, or stabilization of the AR protein [7], recently linked to the phosphorylation of some AR residues [8], [9].
Phosphorylation (phosphorylation) of AR
1) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.63 Pain Relevance 0.16
The IL-1 stimulation of mitogen-activated protein/ERK kinase kinases (MEKK) results in phosphorylation of TAB2, an AR-interacting protein, which resulted in and release of the TAB2/N-CoR holocorepressor complex from the androgen receptor.
Phosphorylation (phosphorylation) of AR
2) Confidence 0.61 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.38 Pain Relevance 0.21
In the absence of androgens, MAPK and AKT kinases may induce AR phosphorylation and activation, whereas STAT3 can bind ligand-free AR and facilitate its translocation to the nucleus.
Phosphorylation (phosphorylation) of AR in nucleus
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.29 Pain Relevance 0
In patients, AR overexpression can result from gene amplification, increased transcription, or stabilization of the AR protein [7], recently linked to the phosphorylation of some AR residues [8], [9].
Phosphorylation (phosphorylation) of AR
4) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.62 Pain Relevance 0.15
Phosphorylated ERK (ERKpp) activated AR (pAR), and the transcription factors AP1 and ETS all showed a below additive response (Fig. 9B).
Phosphorylation (Phosphorylated) of AR
5) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.12 Pain Relevance 0
Experimentally, Asc should therefore significantly retard agonist-stimulated phosphorylation of the AR, as has previously been demonstrated for combinations of agonists with antagonists [23] and chronic beta-blockers [24].
Phosphorylation (phosphorylation) of AR associated with beta blocker, antagonist and agonist
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.35
Moreover, it is possible that once the AR is phosphorylated, binding of Asc to it (in the presence of agonist) may permit a receptor conformation modification that causes rapid dephosphorylation of the receptor, returning it to its high sensitivity state.
Phosphorylation (phosphorylated) of AR associated with agonist
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.34

General Comments

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