INT213381

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.41
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (STX1A) vesicle-mediated transport (STX1A) extracellular region (STX1A)
plasma membrane (STX1A) protein binding, bridging (STX1A) protein complex (STX1A)
Anatomy Link Frequency
vesicle 1
STX1A (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 73 100.00 Very High Very High Very High
bDMF 1 99.88 Very High Very High Very High
Neurotransmitter 6 96.20 Very High Very High Very High
Glutamate receptor 5 49.36 Quite Low
antagonist 22 49.04 Quite Low
agonist 16 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 38 97.68 Very High Very High Very High
Infection 4 92.92 High High
Cancer 198 91.20 High High
Acute Renal Failure 5 88.04 High High
Thrombocytopenia 3 85.92 High High
Hemolytic Anemia 2 82.80 Quite High
Hemolytic Uremic Syndrome 41 81.52 Quite High
Obesity 3 78.16 Quite High
Apoptosis 30 77.16 Quite High
Urinary Tract Infection 1 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it is noteworthy that RNAseL/HPC1 is one of the major susceptibility genes identified in familial prostate cancers [25].
Gene_expression (/) of HPC1 associated with prostate cancer
1) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.92 Pain Relevance 0
In addition, it is noteworthy that RNAseL/HPC1 is one of the major susceptibility genes identified in familial prostate cancers [25].
Gene_expression (one) of HPC1 associated with prostate cancer
2) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.92 Pain Relevance 0
Interestingly, recent studies have shown that both STX and TTX can be present in pufferfish, and thus using an LC/MS method can be advantageous in outbreak samples to identify the causative agent of illness [21].
Gene_expression (present) of STX associated with tetrodotoxin
3) Confidence 0.58 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857369 Disease Relevance 0.07 Pain Relevance 0.58
Our microarray analysis revealed increased expression of synaptic protein mRNA involved in the synaptic vesicle pathway, such as Synaptotagmin (SYT), Phospholipase D1 (PLD1) Syntaxin 1A (STX1A), Brain derived neurotrophic factor (BDNF) and FGF7, favoring the presynaptic vesicle clustering (Figure 3).
Gene_expression (expression) of STX1A in vesicle associated with bdmf
4) Confidence 0.38 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.44 Pain Relevance 0.12
Fecal isolates were positive for Stx2-producing E. coli O157:H7 in three cases and in the fourth case for Stx1- and Stx2- producing E. coli O98:H21.
Gene_expression (producing) of Stx1
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 1.06 Pain Relevance 0

General Comments

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